| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Arylacetamide deacetylase-like 2, 311-, AADACL2 |
| Entrez GeneID | 344752 |
| WB Predicted band size | 46.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AADACL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-182 amino acids from the Central region of human AADACL2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于AADACL2抗体的3篇模拟参考文献示例(注：因文献数据库访问限制，以下为学术写作格式示例，建议通过PubMed或Google Scholar核实具体文献)：
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1. **Title**: "AADACL2 as a Novel Regulator of Lipid Metabolism in Hepatocytes"
**Authors**: Tanaka M, et al.
**Summary**: 研究通过AADACL2特异性抗体发现其在肝细胞中调控脂质水解的关键作用，并揭示其表达异常与代谢综合征的关联。
2. **Title**: "Development of a Monoclonal Antibody for Detecting AADACL2 in Colorectal Cancer Tissues"
**Authors**: Chen L, et al.
**Summary**: 报道一种高特异性抗AADACL2单克隆抗体的开发，验证其在结直肠癌组织中过表达的现象，提示其作为潜在生物标志物的价值。
3. **Title**: "Structural Insights into AADACL2 Enzyme Activity via Antibody-mediated Crystallization"
**Authors**: Wagner S, et al.
**Summary**: 利用AADACL2抗体辅助结晶技术解析该酶的三维结构，阐明其底物结合域及催化机制，为药物靶点设计提供依据。
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建议通过以下关键词检索真实文献：
`AADACL2 antibody`, `arylacetamide deacetylase-like 2`, `enzyme function`, `cancer/metabolism`。
The AADACL2 (arylacetamide deacetylase-like 2) antibody is a tool used to study the AADACL2 protein, a member of the hydrolytic enzyme family with structural similarity to arylacetamide deacetylase (AADAC). AADACL2 is implicated in lipid metabolism and xenobiotic processing, though its precise biological functions remain under investigation. The enzyme is thought to hydrolyze endogenous substrates, such as lipid esters or retinol derivatives, and may participate in drug metabolism pathways, similar to AADAC. AADACL2 expression is primarily observed in the liver, adrenal glands, and certain cancer tissues, suggesting roles in both normal physiology and disease contexts.
Antibodies targeting AADACL2 enable the detection and localization of the protein in cells and tissues using techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are typically raised in host species (e.g., rabbits or mice) using immunogenic peptide sequences specific to AADACL2. ensuring minimal cross-reactivity with related enzymes like AADAC or AADACL3. Validated applications include exploring AADACL2's involvement in metabolic disorders, drug resistance, or cancer progression, where altered expression patterns have been reported. Recent studies highlight its potential as a biomarker in hepatocellular carcinoma and its interaction with chemotherapeutic agents, underscoring its relevance in translational research. Robust antibody validation via knockout controls or siRNA knockdown is critical due to shared homology within this enzyme family.
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