Rabbit Polyclonal HLA-DPB1 Antibody

The HLA-DPB1 gene, part of the human major histocompatibility complex (MHC) class II region on chromosome 6. encodes the beta chain of the HLA-DP heterodimer. HLA-DP molecules present exogenous antigens to CD4+ T cells, playing a critical role in adaptive immune responses. HLA-DPB1 antibodies are alloantibodies targeting epitopes on the HLA-DPβ1 chain, often arising from sensitization events such as blood transfusions, pregnancies, or previous organ transplants. These antibodies are increasingly recognized as clinically significant in transplantation, particularly in hematopoietic stem cell and solid organ transplants, where mismatches or antibody presence correlate with graft rejection, graft-versus-host disease (GVHD), or poor outcomes. HLA-DPB1 exhibits high polymorphism, with over 1.500 alleles identified, contributing to antigenic diversity. Antibody detection relies on solid-phase assays like single-antigen bead technology. Notably, HLA-DPB1 permissivity in mismatches (based on T-cell epitope compatibility) influences transplant risk stratification. Beyond transplantation, HLA-DPB1 associations with autoimmune diseases (e.g., rheumatoid arthritis) and infection responses highlight its broader immunologic relevance. Research continues to refine its role in immune-mediated conditions and improve donor-recipient matching strategies.