Rabbit Polyclonal NTF3 Antibody

Neurotrophin-3 (NTF3), a member of the neurotrophin family, plays critical roles in neuronal survival, differentiation, and synaptic plasticity by binding to its high-affinity receptor TrkC and the low-affinity p75NTR receptor. It is essential for the development and maintenance of both the central and peripheral nervous systems, particularly in sensory neurons, sympathetic ganglia, and motor neurons. NTF3 antibodies are tools designed to detect, quantify, or inhibit NTF3 protein expression in research or diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study NTF3's spatial and temporal expression patterns in tissues, its role in neural circuit formation, and its involvement in diseases such as neurodevelopmental disorders, neurodegenerative conditions, and cancers. For example, altered NTF3 signaling has been linked to neuroblastoma, glioblastoma, and chronic pain syndromes. Researchers also utilize NTF3 antibodies to explore therapeutic strategies, including neuroprotection in spinal cord injuries or modulating synaptic function in psychiatric disorders. Validation of antibody specificity via knockout controls or blocking assays is crucial, as off-target binding can compromise data reliability. Commercial NTF3 antibodies are typically raised in rabbits or mice, with monoclonal variants offering higher specificity for consistent experimental outcomes.