| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Mimecan, Osteoglycin, Osteoinductive factor, OIF, OGN, OIF, SLRR3A |
| Entrez GeneID | 4969 |
| WB Predicted band size | 33.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This OGN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 246-276 amino acids from the C-terminal region of human OGN. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,1%BSA and 50% glycerol.prepared by Saturated Ammonium Sulfate (SAS) . |
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以下是3篇与OGN抗体相关的文献示例(注：文献为虚拟构造，仅供参考实际文献需通过学术数据库检索确认)：
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1. **文献名称**: *"Osteoglycin (OGN) as a Novel Biomarker in Cardiac Fibrosis: Immunohistochemical Analysis Using a Polyclonal Antibody"*
**作者**: Smith A, et al.
**摘要**: 本研究通过开发兔源多克隆OGN抗体，验证其在心肌组织中的特异性，发现OGN在纤维化心脏组织中显著上调，提示其可能通过调节TGF-β通路参与纤维化进程。
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2. **文献名称**: *"Monoclonal Antibody-Based Detection of Osteoglycin in Human Osteosarcoma Tissues"*
**作者**: Chen L, et al.
**摘要**: 文章报道了一种高特异性OGN单克隆抗体的制备，并用于骨肉瘤患者组织切片分析，结果表明OGN低表达与肿瘤转移相关，可能作为预后标志物。
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3. **文献名称**: *"OGN Antibody Validation in Zebrafish Models: Implications for Skeletal Development Studies"*
**作者**: Tanaka K, et al.
**摘要**: 研究通过Western blot和免疫荧光验证了OGN抗体在斑马鱼模型中的交叉反应性，发现OGN在骨骼发育早期阶段表达动态变化，支持其在细胞外基质组装中的作用。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词如 **"Osteoglycin antibody"** 或 **"OGN immunohistochemistry"**，并筛选近5年高被引研究。
OGN (osteoglycin), also known as mimecan, is a small leucine-rich repeat proteoglycan (SLRP) primarily found in the extracellular matrix (ECM). It plays a regulatory role in collagen fibril organization, tissue development, and cellular signaling. OGN is expressed in various tissues, including bone, cartilage, heart, and blood vessels, and is implicated in maintaining ECM structural integrity and modulating cell adhesion, proliferation, and differentiation.
OGN antibodies are immunological tools designed to detect and study the expression, localization, and function of the OGN protein. These antibodies are widely used in research applications such as Western blotting, immunohistochemistry, and immunofluorescence to investigate OGN's role in physiological and pathological processes. For instance, OGN has been linked to cardiovascular diseases, fibrotic conditions, and cancer, where it may act as either a tumor suppressor or promoter depending on the context.
In cancer research, OGN antibodies help explore its dual roles—some studies suggest it inhibits tumor growth by regulating ECM remodeling, while others associate it with metastasis promotion. Additionally, OGN's involvement in autoimmune disorders and tissue fibrosis makes its antibodies valuable for diagnostic and therapeutic research. Despite its emerging significance, OGN's precise mechanisms remain partially unclear, necessitating further studies aided by reliable antibody-based detection methods.
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