| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | UBX domain-containing protein 6, UBX domain-containing protein 1, UBXN6, UBXD1, UBXDC2 |
| Entrez GeneID | 80700 |
| WB Predicted band size | 49.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This UBXN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 281-309 amino acids from the C-terminal region of human UBXN6. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于UBXN6 (C-term)抗体的3篇参考文献示例(注：文献为模拟虚构，仅供参考格式，建议通过学术数据库检索真实文献)：
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1. **文献名称**：*UBXN6 interacts with the C-terminal domain of p97/VCP and regulates endoplasmic reticulum-associated degradation*
**作者**：Smith J, et al.
**摘要**：本研究利用UBXN6 (C-term)特异性抗体，通过免疫共沉淀和Western blot技术，揭示了UBXN6通过C端结构域与p97/VCP复合物结合，参与调控内质网相关蛋白降解(ERAD)的分子机制。
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2. **文献名称**：*Characterization of UBXN6 in NF-κB signaling using a C-terminal-specific monoclonal antibody*
**作者**：Chen L, et al.
**摘要**：通过UBXN6 (C-term)抗体，作者证实了UBXN6的C末端在抑制NF-κB信号通路中的关键作用，并发现其缺失会导致炎症因子异常激活，提示UBXN6在炎症性疾病中的潜在治疗价值。
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3. **文献名称**：*Development and validation of a polyclonal antibody targeting the C-terminal region of UBXN6 for functional studies*
**作者**：Wang Y, et al.
**摘要**：该文献报道了一种针对UBXN6 C末端的新型多克隆抗体的开发与验证，通过免疫荧光和蛋白质印迹证实了抗体的特异性，并应用于UBXN6亚细胞定位研究，发现其在细胞质和核周区域的富集现象。
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**建议**：
如需真实文献，可通过PubMed或Google Scholar搜索关键词：
`"UBXN6 C-terminal antibody"`、`"UBXN6 antibody validation"`、`"UBXN6 function"`，并筛选涉及该抗体应用的实验研究(如Western blot、IP、IF等)。部分抗体公司(如Santa Cruz、Abcam)的产品说明书也会引用相关文献。
The UBXN6 (C-term) antibody is designed to target the C-terminal region of the UBXN6 protein, a member of the ubiquitin regulatory X (UBX) domain-containing protein family. UBXN6. also known as UBXD1. plays a role in diverse cellular processes, including endoplasmic reticulum-associated degradation (ERAD), cell cycle regulation, and apoptosis. It interacts with the AAA-ATPase p97/VCP, a key component of the ERAD machinery, facilitating the recognition and processing of ubiquitinated substrates for proteasomal degradation. The C-terminal region of UBXN6 is critical for its functional interactions, particularly in binding to p97/VCP and other cofactors involved in protein quality control pathways.
This antibody is widely used in research to investigate UBXN6 expression, localization, and molecular interactions via techniques like Western blotting, immunoprecipitation, and immunofluorescence. Its specificity for the C-terminal epitope helps distinguish UBXN6 from other UBX family members, aiding studies on its unique roles in cellular homeostasis and disease contexts, such as cancer and neurodegenerative disorders linked to ERAD dysfunction. By enabling precise detection, the antibody contributes to elucidating UBXN6’s regulatory mechanisms in stress response pathways and its potential as a therapeutic target.
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