Rabbit Polyclonal ABCC3 Antibody

The ABCC3 antibody is designed to detect ATP-binding cassette subfamily C member 3 (ABCC3), a transmembrane protein also known as multidrug resistance-associated protein 3 (MRP3). ABCC3 belongs to the ABC transporter superfamily, which facilitates the ATP-dependent transport of various substrates across cellular membranes. Primarily expressed in the liver, intestine, and adrenal glands, ABCC3 plays a critical role in extruding endogenous metabolites (e.g., bile acids, conjugated steroids) and xenobiotics (e.g., drugs, toxins) from cells, contributing to detoxification and multidrug resistance in cancers. Its overexpression in tumors is often linked to chemotherapeutic resistance by reducing intracellular drug accumulation. ABCC3 antibodies are essential tools for studying the protein's expression, localization, and function in normal physiology and disease contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate ABCC3's role in liver disorders, cancer progression, and drug metabolism. Validated antibodies help identify ABCC3 as a potential biomarker for prognosis or a therapeutic target. Researchers also utilize these antibodies to explore tissue-specific regulation under pathological conditions, such as cholestasis or inflammation, where ABCC3 expression may be dynamically modulated.