| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, mRNA cap-binding protein type 3, EIF4E2, EIF4EL3 |
| Entrez GeneID | 9470 |
| WB Predicted band size | 28.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This EIF4E2 antibody is generated from rabbits immunized with human EIF4E2 recombinant protein. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及EIF4E2抗体的研究文献，包含标题、作者及摘要核心内容：
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1. **文献名称**: *"EIF4E2-Dependent Translation in Hypoxia Supports Tumor Cell Adaptation"*
**作者**: Robichaud et al. (2018)
**摘要**: 研究揭示了EIF4E2在低氧条件下通过选择性翻译调控促存活蛋白的机制，使用EIF4E2特异性抗体验证其在肿瘤细胞中的表达及功能，表明其通过mTOR非依赖途径促进癌症适应缺氧微环境。
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2. **文献名称**: *"Differential Roles of eIF4E Family Members in mRNA Translation"*
**作者**: Hernández et al. (2020)
**摘要**: 通过免疫沉淀结合Western blot(使用EIF4E2抗体)，对比了EIF4E1、EIF4E2和EIF4E3的翻译调控功能，发现EIF4E2优先结合特定mRNA 5'UTR，在应激条件下维持关键基因表达。
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3. **文献名称**: *"EIF4E2 as a Biomarker for Ovarian Cancer Progression"*
**作者**: Liu et al. (2019)
**摘要**: 利用EIF4E2抗体检测卵巢癌组织样本，发现其高表达与患者不良预后相关，并通过体外实验证明敲低EIF4E2可抑制肿瘤侵袭，提示其作为潜在治疗靶点。
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**备注**：若需获取具体抗体货号或实验方法细节，建议查阅相关论文的Materials and Methods部分或引用抗体生产商的技术文档。
The eukaryotic initiation factor 4E homolog 2 (EIF4E2), also known as 4EHP, is a member of the eIF4E family of translation initiation factors that play critical roles in cap-dependent mRNA translation. Unlike the canonical eIF4E (EIF4E1), which promotes protein synthesis by binding the 5' cap structure of mRNAs, EIF4E2 is a repressive paralog involved in translational regulation under specific cellular conditions. It suppresses translation by competing with eIF4E1 for cap-binding or by forming inhibitory complexes with other proteins, such as the hypoxia-inducible factor (HIF) during oxygen stress. EIF4E2 is implicated in cellular stress responses, tumor suppression, and developmental processes, making it a focus in studies of cancer, neurobiology, and adaptive metabolism.
EIF4E2 antibodies are essential tools for detecting and quantifying EIF4E2 protein expression, localization, and interaction partners. These antibodies enable researchers to investigate its regulatory mechanisms in translation control, particularly in hypoxia, nutrient deprivation, or oncogenic contexts. Validated for applications like Western blotting, immunofluorescence, and co-immunoprecipitation, high-quality EIF4E2 antibodies exhibit specificity to distinguish it from other eIF4E family members. Recent studies highlight its role in modulating mRNA subsets linked to angiogenesis, cell proliferation, and stress adaptation, underscoring its therapeutic potential. Understanding EIF4E2 dynamics through antibody-based assays contributes to insights into translational reprogramming in disease and development.
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