关键信息
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基因名
MYH2
- 应用
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别名
MYH2；MYHSA2；Myosin-2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UKX2
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表达区间
全长
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氨基酸序列
full
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
MYH2, a member of the myosin heavy chain gene family, plays a crucial role in muscle contraction and has been implicated in various myopathies. Research on MYH2 recombinant proteins has gained significant attention due to the gene's association with congenital muscle disorders, particularly those affecting skeletal muscle tissues. Mutations in the MYH2 gene can lead to phenotypes characterized by weakness and muscle fiber type abnormalities. Understanding the structure and function of MYH2 is essential for elucidating its role in muscle physiology and pathology. Scientists use recombinant protein techniques to produce MYH2 in model systems, allowing for detailed studies on its biochemical properties, interactions with other muscle proteins, and the effects of specific mutations. This research not only aids in deciphering the molecular underpinnings of MYH2-related diseases but also paves the way for potential therapeutic strategies, including gene therapy and targeted treatments aimed at restoring normal muscle function. Through these studies, significant insights into muscle biology and the broader framework of muscle-related conditions can be achieved, fostering advancements in clinical approaches to manage myopathies linked to MYH2.
