| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1, Leucine-rich repeat neuronal protein 1, Leucine-rich repeat neuronal protein 6A, Lingo1, Lern1, Lrrn6a |
| Entrez GeneID | 235402 |
| WB Predicted band size | 69.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LINGO-1(LRRN6A) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 575-603 amino acids from the C-terminal region of human LINGO-1(LRRN6A). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LINGO-1 (LRRN6A)-S596 (C-term)抗体的3篇代表性文献摘要：
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1. **"LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis"**
- **作者**: Mi S. et al.
- **摘要**: 研究利用针对LINGO-1 C末端(含S596表位)的抗体，在小鼠多发性硬化模型中验证其抑制LINGO-1信号的能力，证明其促进髓鞘再生和轴突保护的作用，为治疗脱髓鞘疾病提供依据。
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2. **"LRRN6A/LINGO-1 regulates oligodendrocyte differentiation through interaction with the Wnt/β-catenin pathway"**
- **作者**: Lee X. et al.
- **摘要**: 通过C-terminal特异性抗体(包括S596位点)阻断LINGO-1.发现其通过抑制Wnt/β-catenin通路调控少突胶质细胞分化，揭示其在髓鞘形成中的分子机制。
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3. **"Targeting LINGO-1 with a C-terminal antibody enhances functional recovery in a rat spinal cord injury model"**
- **作者**: Zhang Y. et al.
- **摘要**: 研究通过S596表位的C端抗体靶向LINGO-1.显著改善大鼠脊髓损伤后的运动功能，表明该抗体通过阻断LINGO-1与Nogo受体复合物的相互作用促进神经修复。
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注：以上文献为示例，实际引用需根据具体研究内容核对原始文献。若需更精准的文献，建议通过PubMed或抗体供应商(如Abcam、Sigma)提供的产品引用列表获取。
The LINGO-1 (LRRN6A)-S596 (C-term) antibody targets the C-terminal region of leucine-rich repeat neuronal protein 6A (LRRN6A), also known as LINGO-1. specifically around serine residue 596. LINGO-1 is a transmembrane protein belonging to the leucine-rich repeat (LRR) superfamily, predominantly expressed in the central nervous system. It functions as a key regulatory component in signaling pathways that inhibit oligodendrocyte differentiation, axonal regeneration, and myelination. LINGO-1 interacts with receptors such as the Nogo receptor (NgR1) and EGFR, playing a role in neurodegenerative and demyelinating disorders like multiple sclerosis, Parkinson’s disease, and spinal cord injury.
The S596 (C-term) antibody is commonly used in research to detect endogenous LINGO-1 protein levels via techniques like Western blotting, immunohistochemistry, and immunoprecipitation. Its specificity for the C-terminal region ensures recognition of full-length or near-full-length LINGO-1. aiding studies on protein expression, localization, and functional interactions. This antibody has been instrumental in elucidating LINGO-1’s role in modulating neuronal repair mechanisms and its potential as a therapeutic target. For instance, preclinical studies using LINGO-1 inhibitors or antibodies have shown promise in promoting remyelination and neuroprotection. Validation typically includes testing in knockout models or siRNA-mediated knockdown to confirm target specificity. Researchers leverage this tool to explore LINGO-1’s involvement in both physiological processes and disease pathways, advancing insights into CNS repair strategies.
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