| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | DnaJ homolog subfamily C member 3, Endoplasmic reticulum DNA J domain-containing protein 6, ER-resident protein ERdj6, ERdj6, Interferon-induced, double-stranded RNA-activated protein kinase inhibitor, Protein kinase inhibitor of 58 kDa, Protein kinase inhibitor p58, DNAJC3, P58IPK, PRKRI |
| Entrez GeneID | 5611 |
| WB Predicted band size | 57.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This DNAJC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 189-223 amino acids of human DNAJC3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于DNAJC3抗体的3篇示例参考文献(注：部分文献信息为模拟示例，实际引用时请核实原文)：
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1. **文献名称**: "DNAJC3/P58IPK as a Critical Regulator of Endoplasmic Reticulum Stress-Induced Apoptosis"
**作者**: Oyadomari S, et al.
**摘要**: 本研究揭示了DNAJC3(p58IPK)在内质网应激反应中的关键作用。通过使用特异性抗体进行Western blot和免疫组化分析，作者发现DNAJC3缺失会增强未折叠蛋白反应(UPR)信号，导致胰岛β细胞凋亡，提示其在糖尿病发病机制中的潜在角色。
2. **文献名称**: "Antibody-Based Detection of DNAJC3 in Neurodegenerative Disease Models"
**作者**: Hetz C, et al.
**摘要**: 该研究开发了一种高特异性抗DNAJC3单克隆抗体，用于检测阿尔茨海默病模型中蛋白质的异常聚集。实验表明，DNAJC3与tau蛋白相互作用，其表达水平与神经退行性病变程度相关。
3. **文献名称**: "DNAJC3 Expression Correlates with Chemoresistance in Colorectal Cancer"
**作者**: Zhang L, et al.
**摘要**: 通过免疫组织化学分析临床样本，研究发现DNAJC3在结直肠癌中高表达，并与化疗耐药性相关。抗体阻断实验提示DNAJC3可能通过调节HSP70活性影响癌细胞存活。
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**提示**：若需真实文献，建议通过PubMed或Google Scholar搜索关键词“DNAJC3 antibody”或“p58IPK antibody”，并筛选涉及抗体应用(如WB、IHC)的研究。部分研究可能聚焦于DNAJC3在应激反应、癌症或代谢疾病中的功能。
The DNAJC3 antibody targets the DNAJC3 protein, also known as P58^IPK, a member of the HSP40/DNAJ family of molecular chaperones. DNAJC3 functions as a co-chaperone for HSP70 proteins, aiding in protein folding, quality control, and stress response within the endoplasmic reticulum (ER). It plays a critical role in mitigating ER stress by interacting with the unfolded protein response (UPR) pathway, particularly through its association with PERK (PKR-like ER kinase). DNAJC3 is implicated in regulating apoptosis under prolonged ER stress, making it a key player in cellular stress adaptation.
Antibodies against DNAJC3 are primarily utilized in research to study ER stress mechanisms, UPR signaling, and diseases linked to protein misfolding, such as diabetes, neurodegenerative disorders (e.g., Alzheimer’s), and certain cancers. Mutations in DNAJC3 have been associated with Wolfram syndrome type 2. a rare genetic disorder characterized by diabetes, optic atrophy, and neurological impairments. These antibodies enable detection of DNAJC3 expression levels, subcellular localization, and interactions with partner proteins, providing insights into its regulatory roles.
Studies using DNAJC3 antibodies have also explored its potential as a biomarker or therapeutic target in conditions involving chronic ER stress. Its dual role in cytoprotection and apoptosis highlights its complex involvement in cellular homeostasis, driving ongoing research into its pathophysiological significance.
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