| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein transport protein Sec24B, SEC24-related protein B, SEC24B |
| Entrez GeneID | 10427 |
| WB Predicted band size | 137.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This SEC24B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1209-1239 amino acids from the human region of human SEC24B. |
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以下是关于SEC24B抗体的3篇参考文献示例(注：文献信息为模拟概括，实际引用需核实原文)：
1. **文献名称**：*"SEC24B deficiency promotes colorectal cancer metastasis by inducing epithelial-mesenchymal transition"*
**作者**：Saito K, et al.
**摘要**：该研究通过SEC24B抗体检测发现，SEC24B在结直肠癌组织中表达下调，其缺失通过激活COPII依赖性分泌途径促进肿瘤细胞上皮-间质转化(EMT)，从而增强转移能力。
2. **文献名称**：*"SEC24B regulates neuronal development and autism-related behaviors through ER export of specific cargo proteins"*
**作者**：Wang Y, et al.
**摘要**：利用SEC24B抗体进行免疫组化及Western blot分析，揭示SEC24B在小鼠大脑发育中调控关键突触蛋白的ER-Golgi运输，其功能缺失导致自闭症样行为异常。
3. **文献名称**：*"A high-throughput screen identifies SEC24B inhibitors as potential modulators of COPII-dependent protein secretion"*
**作者**：Johnson R, et al.
**摘要**：研究通过SEC24B抗体验证靶标特异性，筛选出小分子化合物可抑制COPII复合体介导的蛋白分泌，为分泌途径异常相关疾病提供潜在治疗策略。
建议通过PubMed或Google Scholar以“SEC24B antibody”及研究领域关键词检索最新文献。
SEC24B is a crucial component of the COPII (coat protein complex II) machinery, which mediates the formation of transport vesicles from the endoplasmic reticulum (ER) to the Golgi apparatus. As one of four Sec24 paralogs in mammals (Sec24A-D), SEC24B specifically recognizes and sorts cargo proteins into vesicles, ensuring selective trafficking of secretory and membrane proteins. It plays essential roles in cellular homeostasis, development, and disease processes. Mutations or dysregulation of SEC24B have been linked to craniofacial abnormalities, neural tube defects, and cancers, highlighting its importance in tissue morphogenesis and cellular signaling.
SEC24B antibodies are widely used to study COPII assembly, ER-Golgi trafficking mechanisms, and cargo selectivity. They enable detection of SEC24B expression via techniques like Western blotting, immunofluorescence, and immunoprecipitation, helping researchers explore its interactions with other COPII components (e.g., SEC23. SAR1) or cargo adaptors. These antibodies also aid in investigating SEC24B's tissue-specific roles, particularly in organs like the liver, brain, and pancreas, where secretory pathways are critical. Furthermore, they serve as tools to probe pathological contexts, such as tumor metastasis linked to aberrant protein secretion. Commercial SEC24B antibodies are typically raised against conserved epitopes, often validated for cross-reactivity in human, mouse, and rat models. Their applications span basic research, biomarker discovery, and therapeutic target validation.
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