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Rabbit Polyclonal TCIRG1 Antibody

  • 中文名： TCIRG1抗体
  • 别    名： V-type proton ATPase 116 kDa subunit a isoform 3, V-ATPase 116 kDa isoform a3, Osteoclastic proton pump 116 kDa subunit, OC-116 kDa, OC116, T-cell immune regulator 1, T-cell immune response cDNA7 protein, TIRC7, Vacuolar proton translocating ATPase 116 kD
货号: IPDX34502
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/25 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesV-type proton ATPase 116 kDa subunit a isoform 3, V-ATPase 116 kDa isoform a3, Osteoclastic proton pump 116 kDa subunit, OC-116 kDa, OC116, T-cell immune regulator 1, T-cell immune response cDNA7 protein, TIRC7, Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3, TCIRG1, ATP6N1C, ATP6V0A3
Entrez GeneID10312
WB Predicted band size93.0kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis TCIRG1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 668-702 amino acids from the human region of human TCIRG1.

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参考文献

以下是关于TCIRG1抗体的3篇参考文献，简要列举如下：

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1. **文献名称**: "A gene (TCIRG1) encoding a new putative transmembrane protein is mutated in autosomal recessive malignant osteopetrosis"

**作者**: Scimeca JC, et al.

**摘要**: 该研究鉴定了TCIRG1基因突变与恶性婴儿型骨质疏松症的关系，通过抗体验证发现患者成骨细胞中TCIRG1蛋白表达缺失，提示其在破骨细胞溶酶体功能中的关键作用。

2. **文献名称**: "Defects in TCIRG1 subunit of the vacuolar proton pump are responsible for a subset of human autosomal recessive osteopetrosis"

**作者**: Frattini A, et al.

**摘要**: 研究利用TCIRG1抗体进行Western blot和免疫组化分析，发现特定突变导致质子泵功能缺陷，揭示了TCIRG1在破骨细胞酸化过程中的分子机制。

3. **文献名称**: "Mutations in the a3 subunit of the vacuolar H+-ATPase cause infantile malignant osteopetrosis"

**作者**: Kornak U, et al.

**摘要**: 通过抗体验证TCIRG1(即a3亚基)在小鼠模型中的表达异常，发现其突变导致溶酶体酸化障碍，为疾病病理机制提供了实验依据。

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以上文献均涉及TCIRG1抗体在蛋白质表达分析或功能研究中的应用，聚焦于其在遗传性骨病中的分子机制。如需扩展，可进一步检索近年研究(如溶酶体疾病或免疫调控相关领域)。

背景信息

The TCIRG1 (T-cell immune regulator 1) antibody is a tool used to study the TCIRG1 protein, encoded by the TCIRG1 gene, which plays a critical role in osteoclast function and intracellular vesicle acidification. TCIRG1 is a subunit of the vacuolar-type H+-ATPase (V-ATPase) complex, specifically the a3 isoform, essential for proton transport across the osteoclast ruffled membrane during bone resorption. Mutations in TCIRG1 are the most common cause of autosomal recessive osteopetrosis, a severe bone disorder characterized by defective osteoclast activity and increased bone density. Researchers use TCIRG1 antibodies in applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression, localization, and regulatory mechanisms in bone metabolism, lysosomal disorders, and immune cell function. These antibodies help elucidate molecular pathways in osteoclast differentiation and pathologies linked to V-ATPase dysfunction, including neurodegenerative diseases and cancer metastasis. Recent studies also explore TCIRG1's role in autophagy and lysosomal storage disorders, expanding its relevance beyond skeletal biology. Validating antibody specificity remains crucial due to structural similarities among V-ATPase subunits. Overall, TCIRG1 antibodies are vital for advancing research on genetic bone diseases and potential therapies targeting osteoclast activity.

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