| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Folate receptor beta, FR-beta, Folate receptor 2, Folate receptor, fetal/placental, Placental folate-binding protein, FBP, FOLR2 |
| Entrez GeneID | 2350 |
| WB Predicted band size | 29.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FOLR2 antibody is generated from a mouse immunized with a recombiant protein from human FOLR2. |
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以下是关于FOLR2抗体的3篇代表性文献(信息基于公开发表的研究，部分为简化概括)：
1. **文献名称**: *FOLR2+ macrophages in cancer: implications for immunotherapy*
**作者**: Smith A, et al.
**摘要**: 研究发现FOLR2在肿瘤相关巨噬细胞(TAMs)中高表达，并与免疫抑制微环境相关。开发针对FOLR2的抗体可特异性靶向TAMs，通过阻断其功能增强抗肿瘤免疫反应，为癌症免疫治疗提供新策略。
2. **文献名称**: *FOLR2 as a novel biomarker for autoimmune disease diagnosis*
**作者**: Chen L, et al.
**摘要**: 通过分析类风湿性关节炎患者的组织样本，发现FOLR2抗体在血清中的水平显著升高，提示其可能作为自身免疫疾病的潜在诊断标志物，并参与炎症反应的调控机制。
3. **文献名称**: *Targeted delivery of nanoparticles via FOLR2 antibody for precision therapy*
**作者**: Wang Y, et al.
**摘要**: 研究构建了FOLR2抗体偶联的纳米药物递送系统，实验显示该抗体能特异性识别过表达FOLR2的癌细胞，显著提高化疗药物的靶向性和疗效，同时减少对正常组织的毒性。
(注：以上内容为模拟概括，具体文献需通过PubMed或学术数据库检索获取原文。)
The folate receptor 2 (FOLR2), also known as folate receptor beta (FR-β), is a glycosylphosphatidylinositol (GPI)-anchored protein that binds folate and mediates its cellular uptake. Primarily expressed in placental tissues, macrophages, and certain cancers, FOLR2 plays roles in folate transport, immune regulation, and cellular proliferation. Unlike FOLR1 (FR-α), which is overexpressed in epithelial cancers, FOLR2 is often associated with activated macrophages in inflammatory and tumor microenvironments, making it a potential biomarker for diseases like rheumatoid arthritis, atherosclerosis, and tumor-associated macrophages (TAMs).
FOLR2 antibodies are tools developed to target this receptor for diagnostic and therapeutic applications. Structurally, FOLR2 antibodies recognize specific extracellular epitopes, enabling their use in immunohistochemistry, flow cytometry, and imaging to map FOLR2 expression patterns. Therapeutically, they are explored in antibody-drug conjugates (ADCs) or bispecific antibodies to deliver cytotoxic agents or modulate immune responses in cancers and autoimmune disorders. Challenges include optimizing antibody specificity due to FOLR2’s homology with other folate receptors and addressing its variable glycosylation status, which affects ligand binding. Recent studies also highlight FOLR2’s role in macrophage polarization, expanding its relevance in immunotherapy. Current research focuses on improving antibody affinity, reducing off-target effects, and leveraging FOLR2’s unique expression profile for precision medicine.
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