Rabbit Polyclonal BCL2L10 Antibody

The BCL2L10 antibody targets the BCL2-like 10 protein, a member of the BCL-2 family, which regulates apoptosis by modulating mitochondrial outer membrane permeabilization. BCL2L10 (also termed BCL-B or Diva) contains conserved BCL-2 homology (BH) domains and primarily functions as an anti-apoptotic protein, though context-dependent pro-apoptotic roles have been reported. It interacts with other BCL-2 family members (e.g., BAX, BAK, or pro-survival proteins) to influence cell fate. BCL2L10 is implicated in cancer, where its overexpression in tumors like breast, gastric, or colorectal cancers correlates with poor prognosis, therapy resistance, and suppressed apoptosis. It also plays roles in normal physiological processes, including embryonic development and immune regulation. Antibodies against BCL2L10 are critical tools for detecting its expression and localization in tissues or cells via techniques like Western blot, immunohistochemistry, or flow cytometry. Research using these antibodies has helped elucidate BCL2L10's dual roles in apoptosis, its tissue-specific expression patterns, and its potential as a therapeutic target. However, its functional complexity and interactions with diverse signaling pathways necessitate further study to clarify its context-dependent mechanisms in disease and therapy.