| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase 25, 2.7.11.1, Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1, STK25, SOK1, YSK1 |
| Entrez GeneID | 10494 |
| WB Predicted band size | 48.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This STK25 antibody is generated from a rabbit immunized with a recombinant protein of human STK25. |
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以下是3篇与STK25抗体相关的文献示例(文献信息为模拟内容，实际需根据真实文献调整)：
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1. **文献名称**: "STK25 regulates hepatic lipid metabolism through phosphorylation of AMPK"
**作者**: Li, X. et al.
**摘要**: 本研究利用特异性STK25抗体，通过Western blot和免疫组化技术，发现STK25通过磷酸化AMPK通路调控肝脏脂质积累，高脂饮食模型中STK25表达升高与脂肪肝进展相关。
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2. **文献名称**: "STK25 modulates neuronal polarity and dendritic outgrowth via mTOR signaling"
**作者**: Zhang, Y. et al.
**摘要**: 使用STK25抗体进行免疫荧光染色，揭示了STK25在神经元极性形成中的作用，证明其通过调控mTOR信号通路影响树突发育，为神经发育障碍研究提供新机制。
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3. **文献名称**: "STK25 interacts with LKB1 to regulate cell migration in breast cancer"
**作者**: Wang, H. et al.
**摘要**: 通过免疫共沉淀(Co-IP)结合STK25抗体，发现STK25与LKB1蛋白互作，抑制乳腺癌细胞迁移能力，提示其可能作为潜在癌症治疗靶点。
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如需具体文献，建议在PubMed或Web of Science中检索关键词“STK25 antibody”或“STK25 kinase”，并筛选应用该抗体的功能研究论文。
The serine/threonine kinase 25 (STK25), also known as YSK1 or SOK1. is a member of the Ste20-like kinase family, belonging to the germinal center kinase (GCK)-IV subfamily. It plays a critical role in regulating cellular processes such as cell polarity, proliferation, apoptosis, and metabolism. STK25 is notably involved in lipid metabolism and insulin signaling, particularly in the liver, where its dysregulation has been linked to metabolic disorders, including non-alcoholic fatty liver disease (NAFLD) and insulin resistance. The kinase interacts with STRAD and MO25 to form a complex that modulates cell polarity and stress responses, and it is implicated in oxidative stress pathways through its association with the LKB1/STK25 signaling axis.
STK25 antibodies are essential tools for detecting and quantifying STK25 protein expression in research settings. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study STK25's spatial and temporal expression patterns, post-translational modifications, and interactions with binding partners. These antibodies aid in elucidating STK25's role in disease mechanisms, particularly in metabolic syndromes, cancer progression, and neurodegenerative conditions. Commercially available STK25 antibodies are typically developed against specific epitopes, such as the N-terminal or catalytic domains, and are validated for species cross-reactivity (e.g., human, mouse, rat). Researchers rely on these antibodies to explore STK25's therapeutic potential as a biomarker or drug target in metabolic and age-related pathologies.
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