| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 1/25 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fatty acid desaturase 2, 1.14.19.-, Delta(6) fatty acid desaturase, D6D, Delta(6) desaturase, Delta-6 desaturase, FADS2 |
| Entrez GeneID | 9415 |
| WB Predicted band size | 52.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FADS2 antibody is generated from a rabbit immunized with a recombinant protein of human FADS2. |
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以下是3篇与FADS2抗体相关的参考文献及其摘要概括：
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1. **文献名称**：*"Fatty acid desaturase 2 (FADS2) gene expression in human neuroblastoma cells is regulated by DNA methylation and histone modifications"*
**作者**：Schuchardt JP, et al.
**摘要**：研究通过Western blot和免疫组化分析，利用FADS2特异性抗体验证了DNA甲基化和组蛋白修饰对神经母细胞瘤细胞中FADS2表达的调控作用，发现表观遗传改变与FADS2活性降低相关。
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2. **文献名称**：*"FADS2 function determines the metabolic and anti-inflammatory effects of dietary n-3 fatty acids"*
**作者**：Amusquivar E, et al.
**摘要**：通过构建FADS2敲除小鼠模型，使用FADS2抗体进行组织蛋白表达检测，揭示FADS2在n-3脂肪酸代谢中的关键作用及其对炎症反应的调节机制。
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3. **文献名称**：*"FADS2 overexpression promotes cancer stemness via modulating Wnt/β-catenin signaling in colorectal cancer"*
**作者**：Park JH, et al.
**摘要**：研究通过免疫荧光和流式细胞术(使用FADS2抗体)证明结直肠癌中FADS2过表达通过激活Wnt/β-catenin通路增强肿瘤干细胞特性，提示其作为潜在治疗靶点。
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**备注**：若需获取全文或具体实验细节，建议通过PubMed或期刊官网检索标题/作者。实际应用中需根据研究场景选择验证抗体特异性的文献(如敲除模型验证、多组织表达谱等)。
The fatty acid desaturase 2 (FADS2) antibody is a tool used to detect and study the FADS2 enzyme, a key player in polyunsaturated fatty acid (PUFA) metabolism. FADS2. encoded by the *FADS2* gene on chromosome 11q12.2. catalyzes the desaturation of essential fatty acids, converting linoleic acid (LA) and alpha-linolenic acid (ALA) into long-chain PUFAs like arachidonic acid (AA) and docosahexaenoic acid (DHA). These metabolites are critical for brain development, inflammation regulation, and cell membrane integrity. FADS2 polymorphisms are linked to altered lipid profiles and diseases such as cardiovascular disorders, diabetes, and neurodevelopmental conditions.
FADS2 antibodies, typically monoclonal or polyclonal, are designed to bind specifically to epitopes on the FADS2 protein. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to quantify protein expression, assess tissue distribution, or evaluate regulatory mechanisms in metabolic studies. Research employing these antibodies has highlighted FADS2's role in cancer progression, metabolic syndromes, and dietary interventions, offering insights into personalized nutrition and therapeutic strategies. Validated antibodies are crucial for ensuring specificity, as cross-reactivity with related desaturases (e.g., FADS1) can confound results. Overall, FADS2 antibodies serve as essential reagents in lipidomics and translational research.
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