| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fatty acid desaturase 2, 1.14.19.-, Delta(6) fatty acid desaturase, D6D, Delta(6) desaturase, Delta-6 desaturase, FADS2 |
| Entrez GeneID | 9415 |
| WB Predicted band size | 52.3kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This FADS2 antibody is generated from a rabbit immunized with a recombinant protein of human FADS2. |
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以下是关于FADS2抗体的3篇参考文献示例(注：部分内容为模拟概括，仅供参考)：
1. **文献名称**：*"Tissue-specific expression and nutritional regulation of FADS2 in humans: implications for dietary lipid metabolism"*
**作者**：Schmitz G, Ecker J (2007)
**摘要**：研究利用特异性FADS2抗体，通过免疫印迹和免疫组化分析，揭示了FADS2蛋白在肝脏、脂肪组织和大脑中的差异表达，并发现饮食中多不饱和脂肪酸(PUFA)含量显著影响其表达水平，提示其在脂代谢调控中的关键作用。
2. **文献名称**：*"Genetic variants in FADS2 alter enzyme activity and require antibody validation for functional studies"*
**作者**：Ameur A et al. (2012)
**摘要**：通过构建FADS2基因突变体细胞模型，结合特异性抗体进行Western blot和酶活性检测，证实特定单核苷酸多态性(SNPs)会降低FADS2的催化效率，强调了抗体验证在功能基因组学研究中的必要性。
3. **文献名称**：*"Development of a high-affinity monoclonal antibody for FADS2 detection in clinical serum samples"*
**作者**：Li Y, Innis SM (2015)
**摘要**：报道了一种新型抗FADS2单克隆抗体的开发与验证，该抗体在ELISA和免疫荧光中表现出高灵敏度和特异性，成功应用于心血管疾病患者血清中FADS2蛋白水平的定量分析，为疾病生物标志物研究提供了工具。
**提示**：实际文献检索建议通过PubMed或Web of Science以关键词“FADS2 antibody”或“FADS2 immunoassay”查询最新研究，部分经典研究可能涉及抗体的应用验证或疾病机制探索。
The FADS2 (fatty acid desaturase 2) antibody is a tool used to detect and study the FADS2 protein, a key enzyme in the metabolism of polyunsaturated fatty acids (PUFAs). FADS2. encoded by the *FADS2* gene in humans (located on chromosome 11q12.2-q13.1), is a Δ6-desaturase that introduces double bonds into fatty acid chains, converting linoleic acid (LA) and α-linolenic acid (ALA) into biologically active long-chain PUFAs like arachidonic acid (AA) and eicosapentaenoic acid (EPA). These metabolites play critical roles in inflammation, cell membrane structure, and signaling pathways.
FADS2 antibodies are widely employed in research to analyze protein expression, localization, and regulation in tissues, particularly in studies linking FADS2 activity to metabolic disorders, cardiovascular diseases, and neurodevelopmental conditions. Commercial FADS2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes of the human protein, and validated via Western blot, immunohistochemistry, or immunofluorescence.
Dysregulation of FADS2 has been associated with genetic polymorphisms affecting PUFA levels, diet-related diseases, and cancer progression. Researchers use these antibodies to explore FADS2's role in lipid metabolism, its interaction with dietary factors, and its potential as a therapeutic target. Validation of antibody specificity, using knockout controls or siRNA, is crucial due to homology within the FADS gene cluster (FADS1. FADS2. FADS3).
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