| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Ras-related protein Rab-7L1, Rab-7-like protein 1, Ras-related protein Rab-29, RAB29, RAB7L1 |
| Entrez GeneID | 8934 |
| WB Predicted band size | 23.2kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RAB7L1 antibody is generated from a mouse immunized with a recombinant protein of human RAB7L1. |
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以下是关于RAB7L1抗体的3篇参考文献示例(注：文献为虚构示例，实际研究中请替换为真实文献)：
1. **文献名称**: "RAB7L1 regulates lysosomal trafficking and α-synuclein clearance in Parkinson’s disease models"
**作者**: Smith A, et al.
**摘要**: 该研究利用RAB7L1抗体进行Western blot和免疫组化，发现RAB7L1与溶酶体功能相关，敲低RAB7L1导致α-synuclein异常聚集，提示其在帕金森病病理中的作用。
2. **文献名称**: "Interaction between RAB7L1 and LRRK2 in modulating neuronal autophagy"
**作者**: Chen B, et al.
**摘要**: 通过免疫共沉淀(使用RAB7L1抗体)和细胞成像，证明RAB7L1与LRRK2蛋白互作，调控自噬小体形成，影响多巴胺能神经元存活。
3. **文献名称**: "RAB7L1 antibody-based profiling identifies its overexpression in colorectal cancer progression"
**作者**: Lee C, et al.
**摘要**: 采用RAB7L1特异性抗体进行组织芯片分析，发现RAB7L1在结直肠癌中高表达，与肿瘤转移和患者预后不良相关，可能作为潜在生物标志物。
4. **文献名称**: "RAB7L1 modulates mitochondrial-lysosomal crosstalk via antibody-validated protein networks"
**作者**: Gonzalez D, et al.
**摘要**: 结合CRISPR敲除和RAB7L1抗体验证，揭示RAB7L1通过调控线粒体-溶酶体接触位点影响细胞能量代谢，为神经退行性疾病提供新机制。
(注：以上文献信息为模拟生成，实际引用时请核实真实文献。)
The RAB7L1 antibody is a research tool designed to detect and study the RAB7L1 protein, a member of the Rab GTPase family involved in intracellular membrane trafficking and organelle dynamics. RAB7L1 (RAB7-like protein 1), also known as RAB29. regulates vesicular transport pathways, particularly those linked to lysosomal degradation, autophagy, and endosomal sorting. Its functional association with leucine-rich repeat kinase 2 (LRRK2), a protein implicated in Parkinson’s disease (PD), has drawn significant attention. Mutations in LRRK2 and dysregulation of RAB7L1 are linked to impaired lysosomal function and α-synuclein clearance, key pathological features of PD.
RAB7L1 antibodies are commonly used in Western blotting, immunofluorescence, and immunohistochemistry to assess protein expression, localization, and interactions in cellular and disease models. These antibodies help elucidate RAB7L1’s role in maintaining neuronal health, its crosstalk with LRRK2. and its impact on autophagy-lysosomal pathways. Validated antibodies are critical for distinguishing RAB7L1 from other Rab family members and confirming its involvement in PD-related mechanisms. Research utilizing RAB7L1 antibodies has advanced understanding of neurodegenerative processes and potential therapeutic targets, particularly in familial and sporadic forms of Parkinson’s disease. Proper validation, including knockout cell line controls, ensures specificity, making these antibodies essential tools in neuroscience and cell biology studies.
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