| WB | 1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Dihydropyrimidinase-related protein 2, DRP-2, Collapsin response mediator protein 2, CRMP-2, N2A3, Unc-33-like phosphoprotein 2, ULIP-2, DPYSL2, CRMP2, ULIP2 |
| Entrez GeneID | 1808 |
| WB Predicted band size | 62.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This DRP-2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from human DRP-2. |
| Formulation | Purified antibody in TBS with 0.05% sodium azide. |
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以下是关于DRP-2抗体的3篇参考文献示例(内容为模拟生成，非真实文献)：
1. **文献名称**：*Role of DRP-2 in Axonal Transport and Neurodegeneration*
**作者**：Smith J, et al.
**摘要**：本研究利用DRP-2特异性抗体，通过免疫组化和Western blot技术，揭示了DRP-2蛋白在神经元轴突运输中的关键作用，并发现其表达异常与阿尔茨海默病模型中的线粒体功能障碍相关。
2. **文献名称**：*DRP-2 Antibody Validation for Mitochondrial Fission Studies*
**作者**：Chen L, et al.
**摘要**：文章报道了一种新型DRP-2抗体的开发与验证，通过siRNA敲低和免疫荧光共定位实验，证实了该抗体在检测线粒体分裂过程中DRP-2动态分布的可靠性，为相关机制研究提供了工具。
3. **文献名称**：*Dystrophin-Related Protein-2 (DRP-2) in Muscular Dystrophy Pathogenesis*
**作者**：Martinez R, et al.
**摘要**：通过DRP-2抗体对患者肌肉组织样本进行分析，发现DRP-2表达水平与肌营养不良症严重程度呈负相关，提示其可能作为疾病生物标志物或治疗靶点。
(注：如需真实文献，建议通过PubMed或Google Scholar搜索关键词“DRP-2 antibody”或“DRP2 antibody”获取具体研究。)
DRP-2 (Dystrophin-Related Protein 2), also known as utrophin, is a cytoplasmic protein structurally and functionally homologous to dystrophin, a critical component of the muscle cell membrane. It plays a key role in stabilizing the sarcolemma and organizing the cytoskeleton by linking the extracellular matrix to the actin cytoskeleton via the dystrophin-glycoprotein complex (DGC). Unlike dystrophin, which is predominantly expressed in muscle, DRP-2 is widely distributed in non-muscle tissues, including the brain, blood vessels, and neuromuscular junctions, where it contributes to membrane integrity and signaling.
DRP-2 has gained attention due to its compensatory upregulation in Duchenne muscular dystrophy (DMD), a fatal genetic disorder caused by dystrophin deficiency. Studies suggest that enhancing DRP-2 expression could mitigate disease progression by partially substituting dystrophin’s functions. Antibodies targeting DRP-2 are essential tools for detecting its expression, localization, and interactions in both physiological and pathological contexts. These antibodies are widely used in immunohistochemistry, Western blotting, and immunofluorescence to explore DRP-2’s role in cellular mechanics, neuromuscular diseases, and potential therapeutic strategies. Recent research also implicates DRP-2 in cancer and neurodegenerative disorders, broadening its biomedical relevance.
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