Rabbit Polyclonal TXK(N-term) Antibody

The TXK (N-term) antibody targets the N-terminal region of TXK, a non-receptor tyrosine kinase belonging to the Tec family. TXK, also known as RLK or PTK, is predominantly expressed in T cells and natural killer (NK) cells, where it plays a critical role in intracellular signaling cascades triggered by T-cell receptor (TCR) engagement. The N-terminal domain of TXK includes a pleckstrin homology (PH) domain, which facilitates membrane localization and interaction with signaling molecules, and a proline-rich region involved in protein-protein interactions. This antibody is widely utilized in immunological research to investigate TXK's function in TCR-mediated signaling, cytokine production, and T-cell differentiation or activation. It is employed in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to assess TXK expression, phosphorylation status, and subcellular distribution. Studies using this antibody have shed light on TXK's involvement in autoimmune diseases (e.g., rheumatoid arthritis, multiple sclerosis) and cancer, particularly in contexts where T-cell signaling dysregulation contributes to pathogenesis. Its specificity for the N-terminal region makes it valuable for distinguishing TXK from related Tec kinases (e.g., ITK) and for probing structural or functional alterations in disease models.