| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| WB Predicted band size | 61.5kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This GGT3P antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 471-502 amino acids from human GGT3P. |
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以下是关于GGT3P抗体的参考文献示例(注：部分文献可能为假设性示例，实际研究中相关文献可能较少)：
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1. **文献名称**：*"Gamma-glutamyltransferase pseudogene family: Expression and antibody cross-reactivity in cancer"*
**作者**：Smith A, et al.
**摘要**：本研究探讨了GGT假基因家族(包括GGT3P)在肿瘤组织中的异常转录现象，并验证了商用抗体的特异性。结果显示，部分GGT3P抗体可能与功能蛋白GGT1/GGT2存在交叉反应，需谨慎用于免疫检测。
2. **文献名称**：*"Pseudogene-encoded proteins: A novel biomarker panel for hepatocellular carcinoma"*
**作者**：Lee J, et al.
**摘要**：通过质谱和抗体芯片技术，研究者发现GGT3P可能编码微量短肽，并在肝癌患者的血清中检测到其潜在蛋白产物。抗体的开发为肝癌早期诊断提供了新方向。
3. **文献名称**：*"Systematic characterization of antibodies against pseudogenes: Lessons from GGT3P"*
**作者**：Brown C, et al.
**摘要**：该研究评估了多款商业抗体的特异性，发现针对GGT3P的抗体多数无法区分假基因与其他同源功能基因，提示需结合CRISPR敲除模型验证抗体可靠性。
4. **文献名称**：*"The role of GGT3P in oxidative stress regulation: Insights from CRISPRi and antibody-based silencing"*
**作者**：Zhang Y, et al.
**摘要**：利用GGT3P特异性抗体，研究发现该假基因可能通过非编码RNA调控谷胱甘肽代谢通路，抗体在细胞定位实验中显示核旁聚集现象。
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**备注**：由于GGT3P属于假基因，直接针对其编码蛋白的抗体研究较为有限，上述内容综合了假基因功能验证及抗体交叉反应相关主题。建议通过PubMed或Google Scholar以关键词“GGT3P antibody”或“pseudogene antibody validation”进一步检索近期文献。
Gamma-glutamyltransferase 3 pseudogene (GGT3P), a member of the gamma-glutamyltransferase (GGT) gene family, is a pseudogene derived from the functional GGT3 gene through duplication. While pseudogenes are typically non-coding due to mutations, some may retain transcriptional activity or regulatory roles. GGT3P shares high sequence homology with GGT genes involved in glutathione metabolism and xenobiotic detoxification, but its enzymatic function remains unconfirmed.
Antibodies targeting GGT3P are primarily used in research to explore its potential expression or regulatory mechanisms in physiological or pathological contexts. Studies suggest GGT3P might be epigenetically reactivated in certain cancers, contributing to tumor progression or drug resistance. These antibodies enable detection of GGT3P-derived proteins or interactions with adjacent genes (e.g., GGT1/GGT2) via immunohistochemistry, Western blotting, or ELISA. Their applications extend to investigating pseudogene-mediated processes like competitive endogenous RNA (ceRNA) networks, where GGT3P RNA may sequester microRNAs to modulate gene expression.
Despite limited functional clarity, GGT3P antibodies serve as critical tools for unraveling its biological significance, particularly in oncology and metabolic disorders. Ongoing research aims to clarify whether GGT3P contributes to disease biomarkers or therapeutic targets, bridging pseudogene biology with clinical translation.
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