| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein sel-1 homolog 3, Suppressor of lin-12-like protein 3, Sel-1L3, SEL1L3, KIAA0746 |
| Entrez GeneID | 23231 |
| WB Predicted band size | 128.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This K0746 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-282 amino acids from the N-terminal region of human K0746. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于K0746 (N-term)抗体的模拟参考文献示例(注：具体文献可能需要根据实际靶点或供应商信息进一步核实)：
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1. **"Characterization of Novel Kinase Activation Using N-terminal Specific Antibodies"**
*Author: Lee, J. et al.*
**摘要**: 本研究利用K0746 (N-term)抗体通过Western blot和免疫沉淀技术，分析了靶蛋白在激酶信号通路中的N端磷酸化修饰，揭示了其在细胞增殖中的调控作用。
2. **"Localization of Protein X in Neuronal Tissues via Immunohistochemistry"**
*Author: Martinez, R. et al.*
**摘要**: 通过K0746 (N-term)抗体的免疫组化染色，证实了Protein X的N端结构域在神经元突触中的特异性分布，为其神经保护功能提供了证据。
3. **"Dysregulation of Y Protein Expression in Breast Cancer"**
*Author: Chen, H. et al.*
**摘要**: 采用K0746 (N-term)抗体进行流式细胞术和免疫印迹，发现Y蛋白的N端表达水平在乳腺癌组织中显著上调，提示其作为潜在生物标志物的可能性。
4. **"Antibody Validation for Apoptosis-Related Protein Detection"**
*Author: Gupta, S. et al.*
**摘要**: 系统性评估了K0746 (N-term)抗体的特异性，证实其适用于检测靶蛋白在凋亡过程中的N端裂解片段，为相关机制研究提供了可靠工具。
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**说明**：上述文献为模拟示例，实际文献需通过学术数据库(如PubMed)或抗体供应商官网(如Sigma-Aldrich、Abcam)以“K0746 antibody”或靶点名称检索。若需精确结果，建议提供抗体的靶点蛋白或生产商信息。
The K0746 (N-term) antibody is a polyclonal antibody generated against a synthetic peptide or recombinant protein corresponding to the N-terminal region of a specific target protein (exact target depends on the antibody's designated antigen, which should be verified in product documentation). Such antibodies are commonly developed for use in various research applications, including Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP). The "N-term" designation indicates that the antibody recognizes an epitope located within the N-terminal portion of the protein, which may be critical for studying protein function, localization, or post-translational modifications (e.g., phosphorylation, cleavage) in this region.
Produced typically in rabbit or mouse hosts, K0746 (N-term) antibodies undergo validation steps to ensure specificity and sensitivity, often including knockdown/knockout controls or antigen absorption tests. The target protein might be associated with specific cellular pathways, diseases (e.g., cancer, neurodegenerative disorders), or structural functions, depending on its identity. Researchers frequently use such antibodies to investigate protein expression patterns across tissues, subcellular distribution, or changes under experimental conditions (e.g., drug treatments, stress).
For accurate application, users should confirm the antibody’s reactivity (human, mouse, rat, etc.) and recommended dilution ranges via manufacturer datasheets. Always cross-reference with public databases (e.g., UniProt) for protein domain information and experimental conditions reported in peer-reviewed studies.
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