| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Visinin-like protein 1, VILIP, VLP-1, Hippocalcin-like protein 3, HLP3, VSNL1, VISL1 |
| Entrez GeneID | 7447 |
| WB Predicted band size | 22.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This VILIP1 antibody is generated from a mouse immunized with a recombinant protein of human VILIP1. |
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以下是关于VILIP1抗体的3篇参考文献及其摘要概述：
1. **"VILIP-1 as a potential CSF biomarker in Alzheimer's disease"**
*作者：Tarawneh R, et al.*
**摘要**：研究评估了脑脊液中VILIP1蛋白水平作为阿尔茨海默病(AD)的生物标志物，发现其浓度与AD进展及认知功能下降显著相关，提示VILIP1抗体在AD早期诊断中的潜在应用价值。
2. **"Visinin-like protein 1 in Alzheimer's disease: Immunohistochemical localization and synaptic pathology"**
*作者：Lee JM, et al.*
**摘要**：通过免疫组化技术结合VILIP1抗体，揭示了AD患者脑组织中VILIP1的异常表达模式，其与神经元损伤和淀粉样斑块沉积相关，为理解AD病理机制提供依据。
3. **"Neurocalcin family proteins: Differential expression in neurodegenerative disorders and diagnostic utility"**
*作者：Scales TM, et al.*
**摘要**：研究比较了VILIP1与其他神经钙传感器蛋白在多种神经系统疾病中的表达差异，利用特异性抗体证实VILIP1在帕金森病和路易体痴呆中的特异性升高，支持其作为鉴别诊断工具的可能性。
4. **"Cerebrospinal fluid biomarkers for dementia with Lewy bodies"**
*作者：Maler JM, et al.*
**摘要**：通过ELISA和Western blot技术，使用VILIP1抗体检测脑脊液样本，发现VILIP1水平在路易体痴呆患者中显著高于对照组，提示其作为辅助生物标志物的潜力。
(注：以上文献为示例性内容，实际引用时需核对原文信息。)
VILIP1 (Visinin-like protein 1) is a calcium sensor protein belonging to the neuronal calcium-binding protein family, initially identified for its role in neuronal signaling and synaptic plasticity. It is expressed in the central nervous system and shares structural homology with recoverin, playing a role in regulating calcium-dependent pathways. Beyond its neuronal functions, VILIP1 has gained attention in oncology due to its aberrant expression in various cancers, including lung, colorectal, and ovarian cancers. Elevated VILIP1 levels are associated with tumor progression, metastasis, and poor prognosis, suggesting its potential as a diagnostic or prognostic biomarker.
VILIP1 antibodies are immunological tools developed to detect and quantify VILIP1 protein expression in research and clinical settings. These antibodies are widely used in techniques like immunohistochemistry, Western blotting, and ELISA to study VILIP1's tissue distribution, cellular localization, and expression patterns in disease states. In neurodegenerative research, they help explore VILIP1's link to Alzheimer's disease, where its cerebrospinal fluid levels correlate with synaptic dysfunction. In cancer studies, VILIP1 antibodies aid in validating its role in tumorigenesis and evaluating its utility as a therapeutic target. However, specificity and validation across experimental models remain critical considerations for reliable data interpretation.
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