| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein lin-28 homolog B, Lin-28B, LIN28B, CSDD2 |
| Entrez GeneID | 389421 |
| WB Predicted band size | 27.1kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LIN28B antibody is generated from a mouse immunized with a recombinant protein of human LIN28B. |
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以下是3篇与LIN28B抗体相关的文献摘要示例：
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1. **文献名称**：LIN28B promotes colon cancer progression and metastasis
**作者**：King CE, et al.
**摘要**：该研究利用LIN28B特异性抗体，通过免疫组化分析发现LIN28B在结直肠癌组织中高表达，并与转移和不良预后相关。实验表明LIN28B通过调控let-7家族miRNA促进EMT和肿瘤侵袭。
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2. **文献名称**：LIN28B regulates ribosomal protein synthesis and embryonic stem cell differentiation
**作者**：Zhang J, et al.
**摘要**：研究通过Western Blot和免疫荧光(使用抗LIN28B抗体)发现，LIN28B通过结合核糖体RNA前体调控蛋白质翻译速率，影响胚胎干细胞的自我更新和分化时序。
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3. **文献名称**：LIN28B cooperates with mutant KRAS to promote pancreatic cancer progression
**作者**：Riemondy KA, et al.
**摘要**：该研究使用LIN28B抗体进行组织芯片分析，证实LIN28B在胰腺癌中过表达，且与KRAS突变协同激活MAPK/ERK通路，促进肿瘤生长和化疗耐药。
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*注：以上为模拟摘要，实际文献需通过PubMed或Google Scholar检索关键词“LIN28B antibody”或“LIN28B immunohistochemistry”获取。建议查阅近年肿瘤学或分子生物学期刊(如《Nature》《Cancer Research》)以获取准确文献。*
The LIN28B antibody is a key tool for studying the LIN28B protein, an RNA-binding protein involved in post-transcriptional gene regulation. LIN28B, along with its homolog LIN28A, plays critical roles in embryonic development, stem cell pluripotency, and cellular reprogramming by suppressing the biogenesis of let-7 microRNAs, which regulate oncogenes and differentiation factors. Overexpression of LIN28B is associated with multiple cancers, including neuroblastoma, hepatocellular carcinoma, and germ cell tumors, where it promotes tumorigenesis, metastasis, and therapy resistance.
This antibody enables the detection and quantification of LIN28B protein levels in diverse experimental applications such as Western blotting (WB), immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Available in monoclonal or polyclonal formats from hosts like rabbit or mouse, it typically targets conserved regions of the LIN28B protein. Validation often includes testing in LIN28B-knockout cell lines to confirm specificity. Researchers use LIN28B antibodies to explore its oncogenic mechanisms, stem cell dynamics, and tissue-specific expression patterns. Its role in metabolic regulation and developmental timing further expands its research relevance. As a potential cancer biomarker and therapeutic target, LIN28B antibodies are vital for advancing studies in oncology, developmental biology, and regenerative medicine.
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