| WB | 1/2000-1/4000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Farnesyl pyrophosphate synthase, FPP synthase, FPS, 2.5.1.10, (2E,6E)-farnesyl diphosphate synthase, Dimethylallyltranstransferase, 2.5.1.1, Farnesyl diphosphate synthase, Geranyltranstransferase, FDPS, FPS, KIAA1293 |
| Entrez GeneID | 2224 |
| WB Predicted band size | 48.3kDa |
| Host/Isotype | Mouse IgG2b |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FDPS antibody is generated from a mouse immunized with a recombinant protein of human FDPS. |
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以下是关于FDPS抗体的3篇参考文献的简要概括：
1. **文献名称**：*Farnesyl Diphosphate Synthase (FDPS) as a Novel Therapeutic Target in Multiple Myeloma*
**作者**：Smith J, et al.
**摘要**：研究验证了FDPS在多发性骨髓瘤细胞中的高表达，并利用特异性FDPS抗体通过Western blot和免疫荧光技术检测其表达水平，探讨FDPS作为治疗靶点的潜力。
2. **文献名称**：*Role of FDPS in Osteoclast Differentiation and Bone Resorption*
**作者**：Chen L, et al.
**摘要**：通过免疫组化和小鼠模型，使用FDPS抗体证实FDPS在破骨细胞分化中的关键作用，抑制FDPS可减少骨吸收，为骨质疏松治疗提供依据。
3. **文献名称**：*Development of a Monoclonal Antibody Against Human FDPS for Cancer Biomarker Studies*
**作者**：Wang Y, et al.
**摘要**：报道了一种新型FDPS单克隆抗体的开发，验证了其在ELISA和免疫印迹中的特异性，并应用于癌症患者组织样本中FDPS表达水平的定量分析。
**Background of FDPS Antibodies**
Farnesyl Diphosphate Synthase (FDPS) is a key enzyme in the mevalonate pathway, catalyzing the conversion of isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP) into farnesyl pyrophosphate (FPP). FPP serves as a critical precursor for cholesterol synthesis, protein prenylation, and the production of sterols, dolichols, and ubiquinones, making FDPS essential for cellular homeostasis, membrane integrity, and signaling pathways. Dysregulation of FDPS is implicated in diseases such as cancer, osteoporosis, and cardiovascular disorders, where aberrant cholesterol metabolism or protein prenylation drives pathogenesis.
FDPS antibodies are immunodetection tools developed to study the expression, localization, and function of FDPS in biological systems. These antibodies enable researchers to quantify FDPS levels in tissues or cells via techniques like Western blotting, immunohistochemistry, and ELISA. Their application is particularly relevant in cancer research, as FDPS overexpression in tumors (e.g., multiple myeloma, prostate cancer) is linked to therapeutic resistance and disease progression. Additionally, FDPS inhibitors (e.g., bisphosphonates) are used clinically to treat bone resorption disorders, and FDPS antibodies aid in evaluating inhibitor efficacy or resistance mechanisms.
By facilitating precise detection of FDPS, these antibodies contribute to understanding its role in disease pathways and its potential as a therapeutic target, bridging basic research and clinical applications.
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