Rabbit Polyclonal p19(N-term) Antibody

The p19 (N-term) antibody is designed to target the N-terminal region of the p19 protein, a subunit of interleukin-23 (IL-23), a pro-inflammatory cytokine involved in immune regulation. IL-23 is a heterodimeric cytokine composed of two subunits: p19 (specific to IL-23) and p40 (shared with IL-12). The p19 subunit is critical for IL-23's biological activity, particularly in promoting the differentiation and stabilization of Th17 cells, which play key roles in autoimmune diseases, inflammation, and cancer. Antibodies against the N-terminal domain of p19 are often used to specifically detect or neutralize IL-23 in research and therapeutic contexts. These antibodies are valuable tools for studying IL-23-mediated signaling pathways, validating protein expression in immunoassays (e.g., Western blot, ELISA, immunohistochemistry), or developing targeted therapies for conditions like psoriasis, inflammatory bowel disease, or rheumatoid arthritis. The N-terminal region is frequently chosen as an epitope due to its accessibility and structural conservation, ensuring antibody specificity and reducing cross-reactivity with related proteins. p19 (N-term) antibodies are typically produced in hosts such as rabbits or mice, with validation in relevant experimental models to confirm functionality and binding affinity. Their applications span basic research, biomarker discovery, and preclinical drug development.