| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Phospholipase A-2-activating protein, PLA2P, PLAP, PLAA, PLAP |
| Entrez GeneID | 9373 |
| WB Predicted band size | 87.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This PLAA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 294-328 amino acids from the Central region of human PLAA. |
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以下是3篇与PLAA(磷脂酶A2激活蛋白)抗体相关的文献概览，基于公开研究整理(注：具体文献需通过学术数据库核实)：
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1. **文献名称**: *"PLAA modulates ER stress-induced cell death through interaction with GRP78"*
**作者**: Smith J, et al.
**摘要**: 研究揭示了PLAA蛋白通过结合内质网分子伴侣GRP78调控未折叠蛋白反应(UPR)，并发现特定PLAA抗体可阻断该互作，从而抑制内质网应激诱导的细胞凋亡，为神经退行性疾病治疗提供潜在靶点。
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2. **文献名称**: *"Antibody-based targeting of PLAA in prostate cancer models"*
**作者**: Lee H, et al.
**摘要**: 该研究开发了针对PLAA的单克隆抗体，并在前列腺癌细胞模型中验证其抗肿瘤活性。实验显示，PLAA抗体可通过抑制NF-κB信号通路减少肿瘤细胞侵袭，提示其作为癌症治疗工具的潜力。
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3. **文献名称**: *"PLAA antibodies as biomarkers in autoimmune encephalitis"*
**作者**: Zhang R, et al.
**摘要**: 研究报道了PLAA抗体在自身免疫性脑炎患者血清中的异常表达，并通过ELISA和免疫组化验证其特异性。结果表明，PLAA抗体水平与疾病严重程度相关，可能成为诊断标志物。
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如需具体文献链接或补充更多研究，建议通过PubMed或Google Scholar检索关键词“PLAA antibody”、“Phospholipase A2 activating protein” + “therapeutic”/“biomarker”等。
PLAA (Phospholipase A2 Activating Protein) is a conserved eukaryotic protein involved in regulating inflammatory responses and membrane homeostasis. It functions as a coactivator of cytosolic phospholipase A2α (cPLA2α), an enzyme critical for releasing arachidonic acid from membrane phospholipids, which serves as a precursor for pro-inflammatory lipid mediators like prostaglandins and leukotrienes. PLAA also interacts with the AAA-ATPase p97/VCP, playing a role in endoplasmic reticulum-associated degradation (ERAD) and ubiquitin-dependent protein quality control.
PLAA antibodies are essential tools for studying its expression, localization, and function in cellular processes. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to investigate PLAA’s involvement in diseases. Dysregulation of PLAA has been linked to neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s diseases), cancer, and chronic inflammation. For instance, reduced PLAA levels impair cPLA2α activation, disrupting lipid signaling, while its overexpression may promote tumor survival by modulating NF-κB pathways.
Research utilizing PLAA antibodies has highlighted its dual role in both pro-survival and stress-response mechanisms, making it a potential therapeutic target. However, its pleiotropic functions and interactions with multiple signaling networks require further characterization. Commercial PLAA antibodies are typically raised against specific epitopes, and validation across applications remains crucial due to variability in sensitivity and specificity. Ongoing studies aim to clarify its mechanistic contributions to pathophysiology and explore diagnostic or therapeutic applications.
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