| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | A disintegrin and metalloproteinase with thrombospondin motifs 20, ADAM-TS 20, ADAM-TS20, ADAMTS-20, 3.4.24.-, ADAMTS20 |
| Entrez GeneID | 80070 |
| WB Predicted band size | 214.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This ADAMTS20 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 782-816 amino acids from the Central region of human ADAMTS20. |
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以下是关于ADAMTS20抗体的3篇参考文献示例(基于模拟数据，实际文献需通过学术数据库验证)：
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1. **文献名称**：*ADAMTS20 regulates melanoblast migration and differentiation through proteolytic activity*
**作者**：Smith J, et al.
**摘要**：本研究利用ADAMTS20特异性抗体，通过免疫组化和Western blot技术，揭示了ADAMTS20在黑色素细胞迁移和分化中的作用，并发现其缺失导致小鼠模型皮肤色素异常。
2. **文献名称**：*Characterization of a novel polyclonal antibody against ADAMTS20 and its application in colorectal cancer*
**作者**：Li X, et al.
**摘要**：文章报道了一种新开发的兔多克隆ADAMTS20抗体的制备与验证，证实其在人结直肠癌组织中高表达，并提示其与肿瘤侵袭性相关。
3. **文献名称**：*ADAMTS20 mutations and extracellular matrix remodeling in congenital heart disease*
**作者**：Garcia R, et al.
**摘要**：通过ADAMTS20抗体进行免疫荧光染色，研究发现ADAMTS20基因突变会干扰心脏发育过程中的细胞外基质重塑，可能与先天性心脏病相关。
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**说明**：以上文献为示例，实际引用需查询PubMed、Web of Science等平台确认具体信息。若研究较少，可扩展检索关键词(如“ADAMTS家族抗体”或“ADAMTS20功能”)。
The ADAMTS20 antibody is a tool used to study the ADAMTS20 protein, a member of the ADAMTS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) family. This family comprises secreted zinc-dependent metalloproteases involved in extracellular matrix (ECM) remodeling, cell adhesion, and proteolytic processing of bioactive molecules. ADAMTS20. encoded by the ADAMTS20 gene, is less characterized compared to other family members but is implicated in collagen processing, fibrillin microfibril organization, and tissue development. Studies suggest its role in developmental processes, including eye morphogenesis, and potential links to diseases such as cancer, fibrosis, or connective tissue disorders.
ADAMTS20 antibodies are primarily employed in research to detect and quantify protein expression in biological samples (e.g., tissues, cell lysates) using techniques like Western blotting, immunohistochemistry, or immunofluorescence. These antibodies help elucidate the protein’s spatial distribution, regulation, and interactions. Due to limited commercial availability, many ADAMTS20 antibodies are custom-produced, requiring rigorous validation for specificity (e.g., knockout controls) and optimal performance in target applications. Current research focuses on clarifying ADAMTS20’s substrate repertoire, signaling pathways, and therapeutic relevance, particularly in ECM-associated pathologies. However, its exact biological mechanisms and disease associations remain under investigation, highlighting the need for further studies using reliable antibody tools.
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