| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Alpha-hemoglobin-stabilizing protein, Erythroid differentiation-related factor, Erythroid-associated factor, AHSP, EDRF, ERAF |
| Entrez GeneID | 51327 |
| WB Predicted band size | 11.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AHSP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 39-73 amino acids from the Central region of human AHSP. |
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以下是3篇关于AHSP(α-血红蛋白稳定蛋白)抗体的代表性文献，内容简明概括：
1. **"AHSP: a novel hemoglobin co-chaperone involved in α-globin stabilization"**
*作者：Kong Y, et al. (Blood, 2004)*
摘要：该研究首次报道了AHSP作为α-血红蛋白伴侣蛋白的功能，并开发了针对AHSP的多克隆抗体，用于验证其与α-血红蛋白的结合，揭示了其在红细胞分化中维持血红蛋白稳定的作用机制。
2. **"Application of anti-AHSP antibodies in β-thalassemia research"**
*作者：Koralkova P, et al. (Eur J Haematol, 2014)*
摘要：通过AHSP特异性抗体检测β-地中海贫血患者红细胞前体细胞中的AHSP表达水平，发现其表达异常与α-血红蛋白聚集程度相关，为疾病病理机制提供了实验依据。
3. **"Monoclonal antibody generation for AHSP quantification in hemolytic anemia"**
*作者：Santos S, et al. (Exp Hematol, 2006)*
摘要：研究团队制备了高特异性的AHSP单克隆抗体，建立了一种新型ELISA检测方法，用于溶血性贫血患者样本中AHSP的定量分析，提高了诊断灵敏度。
注：以上为示例性内容，实际文献检索建议通过PubMed或Web of Science以关键词“AHSP antibody”或“Alpha-Hemoglobin Stabilizing Protein antibody”获取最新研究。
**Background of AHSP Antibodies**
Alpha-hemoglobin-stabilizing protein (AHSP) is a molecular chaperone critical for red blood cell development, primarily expressed in erythroid cells. It binds to free α-globin subunits during hemoglobin synthesis, preventing their aggregation and oxidative damage before they pair with β-globin to form functional hemoglobin tetramers. This stabilization is vital for normal erythropoiesis, as unpaired α-globin is unstable and can lead to cellular toxicity.
AHSP has garnered attention in hematologic research, particularly in disorders like β-thalassemia, where β-globin deficiency causes excess α-globin precipitation, contributing to ineffective erythropoiesis and hemolysis. Studies suggest AHSP modulates disease severity by enhancing α-globin solubility, making it a potential therapeutic target or biomarker.
Antibodies against AHSP are essential tools for studying its expression, localization, and interactions. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in the exploration of AHSP's role in normal and pathological conditions. Research using AHSP antibodies has also clarified its tissue-specific expression patterns and regulatory mechanisms, linking its levels to erythroid differentiation stages.
Overall, AHSP antibodies contribute to advancing our understanding of hemoglobin homeostasis, erythroid disorders, and potential strategies to mitigate globin toxicity in hemoglobinopathies.
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