| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | HEAT repeat-containing protein 6, Amplified in breast cancer protein 1, HEATR6, ABC1 |
| Entrez GeneID | 63897 |
| WB Predicted band size | 128.8kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | This HEATR6 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 299-331 amino acids from human HEATR6. |
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以下是关于HEATR6 (N-Term)抗体的虚构参考文献示例(实际文献需通过学术数据库验证)：
1. **文献名称**: "HEATR6参与细胞周期调控的分子机制研究"
**作者**: Zhang et al.
**摘要**: 本研究利用HEATR6 (N-Term)抗体进行免疫共沉淀实验，发现HEATR6通过与CDK1相互作用调控G2/M期转换，并影响肿瘤细胞增殖。
2. **文献名称**: "HEATR6在肝癌中的表达及临床意义"
**作者**: Wang et al.
**摘要**: 通过Western blot和免疫组化(使用HEATR6 N端特异性抗体)，证实HEATR6在肝癌组织中高表达，且与患者预后不良显著相关。
3. **文献名称**: "HEATR6蛋白结构及其核定位信号分析"
**作者**: Smith et al.
**摘要**: 采用HEATR6-N-Term抗体进行亚细胞定位研究，发现其N端结构域包含关键核定位序列，对维持蛋白的核内功能至关重要。
4. **文献名称**: "HEATR6与DNA损伤修复通路的关联"
**作者**: Gupta et al.
**摘要**: 通过ChIP-seq(使用N-Term抗体)揭示HEATR6在DNA损伤后富集于修复相关基因启动子区，提示其在基因组稳定性中的作用。
注：以上为模拟内容，实际文献需查阅PubMed、Google Scholar等平台。
The HEATR6 (N-Term) antibody is designed to target the N-terminal region of HEAT Repeat-Containing Protein 6 (HEATR6), a conserved eukaryotic protein involved in diverse cellular processes. HEATR6 belongs to the HEAT-repeat protein family, characterized by tandem repeats of α-helical motifs that mediate protein-protein interactions and structural scaffolding. HEATR6 is implicated in critical functions such as ribosome biogenesis, cell cycle regulation, and chromatin remodeling. Studies suggest its role in coordinating the assembly of the small ribosomal subunit by interacting with ribosome biogenesis factors and pre-rRNA processing components.
The N-terminal region of HEATR6 is critical for its localization and interaction partners. Antibodies targeting this region are valuable tools for investigating HEATR6’s expression, subcellular distribution (primarily nucleolar and nuclear), and molecular interactions via techniques like Western blotting, immunofluorescence, and co-immunoprecipitation. Dysregulation of HEATR6 has been linked to developmental disorders and cancers, underscoring its biological relevance. The HEATR6 (N-Term) antibody, often raised in rabbits or mice with immunogen peptides corresponding to the N-terminal sequence, is validated for specificity in recognizing endogenous HEATR6 across human, mouse, and rat samples. Its applications span basic research in cell biology, cancer mechanisms, and ribosome assembly studies.
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