Mouse Monoclonal RAB14 Antibody

Rab14 antibody is a tool used to detect Rab14. a small GTPase protein belonging to the Rab family, which regulates intracellular membrane trafficking. Rab14 localizes to the Golgi apparatus, endosomes, and plasma membrane, where it facilitates vesicle transport between these compartments. It plays roles in maintaining Golgi structure, cargo sorting, and lipid droplet formation. Studies link Rab14 dysfunction to diseases, including cancer, neurodegenerative disorders, and viral infections (e.g., influenza A virus entry). The antibody enables researchers to study Rab14’s expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Commercial Rab14 antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., human Rab14 amino acids 50-150). Validation includes testing for specificity using knockout cell lines or siRNA-mediated knockdown. Recent research highlights Rab14’s involvement in autophagy, insulin signaling, and epithelial cell polarity, making its antibody valuable for exploring these pathways. However, users should verify cross-reactivity and optimize experimental conditions due to potential variability between antibody batches.