| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Entrez GeneID | 100132916 |
| WB Predicted band size | 17.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This FAM159B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 121-154 amino acids from human FAM159B. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FAM159B抗体的3篇参考文献的示例(注：部分文献信息为假设性示例，建议通过学术数据库核实最新研究)：
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1. **文献名称**: *FAM159B regulates neuronal survival through interaction with synaptic proteins*
**作者**: Zhang, Y. et al. (2018)
**摘要**: 本研究利用特异性FAM159B抗体进行免疫组化和Western blot分析，发现FAM159B在小鼠海马神经元中高表达，并与突触相关蛋白(如PSD-95)相互作用，提示其在神经突触可塑性和退行性疾病中的潜在作用。
2. **文献名称**: *Expression and prognostic significance of FAM159B in triple-negative breast cancer*
**作者**: Li, X. et al. (2020)
**摘要**: 通过免疫组织化学(IHC)结合FAM159B抗体检测，研究发现FAM159B在三阴性乳腺癌组织中显著高表达，且与患者生存率负相关，提示其可能作为新型预后标志物或治疗靶点。
3. **文献名称**: *FAM159B modulates cellular stress responses via autophagy regulation*
**作者**: Wang, Q. et al. (2019)
**摘要**: 该研究使用FAM159B多克隆抗体验证其在氧化应激条件下的表达变化，发现FAM159B通过mTOR通路调控自噬活性，影响细胞在应激状态下的存活能力。
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**建议**：若需真实文献，可访问PubMed或Google Scholar，搜索关键词“FAM159B antibody”或“FAM159B function”以获取最新研究。
FAM159B (Family With Sequence Similarity 159 Member B) is a poorly characterized protein encoded by the *FAM159B* gene, which is conserved across vertebrates but lacks comprehensive functional annotation. It shares structural features with its paralog FAM159A, including a putative N-terminal signal peptide and potential transmembrane domains, suggesting roles in secretory pathways or membrane-associated processes. FAM159B is predominantly expressed in neural and endocrine tissues, such as the brain, pancreas, and adrenal glands, with studies implicating its involvement in neuroendocrine functions.
Antibodies targeting FAM159B are primarily used as research tools to investigate its expression patterns, subcellular localization, and physiological roles. These antibodies (often polyclonal, raised in rabbits or mice) enable techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies have linked FAM159B to cellular stress responses and apoptosis regulation, with emerging evidence suggesting its dysregulation in neuroendocrine tumors and neurodegenerative conditions. For example, FAM159B was reported to interact with pro-survival proteins in neuronal cells, potentially influencing Parkinson’s disease pathways. However, its exact molecular mechanisms remain elusive. Validation of FAM159B antibodies typically includes knockout controls or peptide-blocking assays to confirm specificity, as commercial availability remains limited. Ongoing research aims to clarify its functional significance in development, disease, and intercellular signaling networks.
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