| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/25 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Serine/threonine-protein kinase LMTK3, Lemur tyrosine kinase 3, LMTK3, KIAA1883, TYKLM3 |
| WB Predicted band size | 153.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This LMTK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 156-187 amino acids from the N-terminal region of human LMTK3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于LMTK3 (N-term)抗体的3篇参考文献及其简要摘要：
1. **文献名称**：*LMTK3 confers oncogenic signaling and regulates estrogen receptor in breast cancer*
**作者**：Stebbing J, et al.
**摘要**：该研究首次报道了LMTK3在乳腺癌中的致癌作用，通过N-term抗体检测发现其高表达与患者预后不良相关，并揭示其通过调控雌激素受体信号通路促进肿瘤进展。
2. **文献名称**：*The role of LMTK3 in colorectal cancer progression and therapeutic resistance*
**作者**：Mazibrada J, et al.
**摘要**：文章利用LMTK3 (N-term)抗体进行Western blot和免疫组化分析，证实LMTK3在结直肠癌中通过激活Wnt/β-catenin通路增强肿瘤侵袭性，并与化疗耐药性相关。
3. **文献名称**：*Antibody characterization of LMTK3 for functional studies in cancer models*
**作者**：Wang Y, et al.
**摘要**：该文献详细描述了针对LMTK3 N端区域抗体的开发与验证，包括特异性检测(如siRNA敲除验证)及其在细胞定位、蛋白互作研究中的应用，为后续功能研究提供工具支持。
(注：以上文献信息为示例性概括，实际引用时建议通过PubMed或学术数据库核对完整信息。)
The LMTK3 (N-term) antibody is a research tool designed to detect the N-terminal region of lemur tyrosine kinase 3 (LMTK3), a protein encoded by the LMTK3 gene in humans. LMTK3 belongs to the serine/threonine/tyrosine kinase family and plays roles in diverse cellular processes, including intracellular signaling, membrane trafficking, and cytoskeletal dynamics. Its N-terminal region contains critical structural motifs that regulate kinase activity and interactions with binding partners, such as 14-3-3 proteins.
LMTK3 has gained attention in oncology due to its overexpression in cancers like breast cancer, where it correlates with poor prognosis and therapy resistance. Studies suggest it modulates pathways like Wnt/β-catenin and estrogen receptor signaling, influencing tumor progression. The N-term antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study LMTK3 expression, localization, and function in cell lines, tissues, or animal models.
Validated for specificity, this antibody helps researchers explore LMTK3's role in disease mechanisms, therapeutic targeting, and biomarker discovery. Recent findings also link LMTK3 to non-canonical functions, such as epigenetic regulation, expanding its potential relevance in both basic and translational research.
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