| WB | 1/1000-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Glutaminase liver isoform, mitochondrial, GLS, 3.5.1.2, L-glutaminase, L-glutamine amidohydrolase, GLS2, GA |
| Entrez GeneID | 27165 |
| WB Predicted band size | 66.3kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This GLS2 antibody is generated from a mouse immunized with a recombinant protein of human GLS2. |
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以下是3篇关于GLS2抗体的文献摘要信息整理(基于公开研究数据，非真实文献引用，仅供参考格式)：
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1. **文献名称**: *GLS2 suppresses tumorigenesis in hepatocellular carcinoma by modulating oxidative phosphorylation*
**作者**: Zhang J. et al.
**摘要**: 本研究利用GLS2特异性抗体通过免疫组化技术，发现GLS2在肝癌组织中表达下调。实验表明GLS2通过调控线粒体氧化磷酸化抑制肿瘤生长，其抗体在检测蛋白定位中验证了GLS2与代谢通路的相关性。
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2. **文献名称**: *The role of GLS2 in regulating p53-mediated antioxidant response*
**作者**: Suzuki S. et al.
**摘要**: 作者通过Western blot(使用兔源GLS2单克隆抗体)揭示GLS2作为p53靶基因，在抗氧化应激中起关键作用。抗体的特异性验证显示GLS2在DNA损伤后表达升高，提示其潜在肿瘤抑制功能。
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3. **文献名称**: *GLS2 isoform-specific antibody reveals distinct roles in neuroblastoma differentiation*
**作者**: Hu W. et al.
**摘要**: 该研究开发了一种针对GLS2不同剪接变体的特异性抗体，证实GLS2长亚型在神经母细胞瘤分化中的独特作用。抗体应用显示GLS2与神经元标志物共定位，为靶向治疗提供新方向。
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4. **文献名称**: *Antibody-based profiling of GLS2 in glioblastoma identifies metabolic vulnerabilities*
**作者**: Cheng T. et al.
**摘要**: 通过免疫荧光(GLS2多克隆抗体)和质谱分析，发现胶质母细胞瘤中GLS2低表达与谷氨酰胺代谢异常相关。抗体检测结果提示GLS2缺失可能促进肿瘤微环境酸化，影响治疗耐药性。
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(注：以上文献为虚构示例，实际研究中需通过PubMed/Google Scholar等平台以关键词“GLS2 antibody”或“glutaminase 2”检索真实文献。)
The GLS2 antibody is a tool used to detect and study glutaminase 2 (GLS2), a key enzyme in glutamine metabolism. GLS2. primarily expressed in the liver and certain cancer cells, catalyzes the hydrolysis of glutamine to glutamate, playing a critical role in cellular energy production, redox balance, and nucleotide synthesis. Unlike its isoform GLS1. which is associated with cancer cell proliferation, GLS2 has dual roles as both a metabolic enzyme and a tumor suppressor. It is transcriptionally regulated by p53 and implicated in modulating oxidative stress responses and apoptosis.
Research using GLS2 antibodies has helped uncover its involvement in hepatocellular carcinoma (HCC), where its downregulation correlates with poor prognosis, and in breast cancer, where it may suppress metastasis. These antibodies are widely employed in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess GLS2 expression levels, subcellular localization, and interactions in disease models. Recent studies also explore its potential neuroprotective functions in neurodegenerative disorders. The development of specific GLS2 antibodies has been crucial for advancing our understanding of its tissue-specific functions, regulatory mechanisms, and therapeutic potential in metabolic and oncological research.
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