| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Fermitin family homolog 3, Kindlin-3, MIG2-like protein, Unc-112-related protein 2, FERMT3, KIND3, MIG2B, URP2 |
| Entrez GeneID | 83706 |
| WB Predicted band size | 76.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This FERMT3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 117-151 amino acids of mouse FERMT3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于FERMT3 (N-Term)抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**: *Kindlin-3 is required for β2 integrin-mediated leukocyte adhesion to endothelial cells*
**作者**: Moser M, et al.
**摘要**: 该研究通过使用针对FERMT3(N端)的抗体，证实Kindlin-3在白细胞β2整合素依赖性黏附中的关键作用。实验显示，FERMT3缺失导致白细胞无法与内皮细胞稳定结合，揭示了其在炎症反应中的分子机制。
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2. **文献名称**: *Loss of Kindlin-3 in platelets prevents arterial thrombosis in mice*
**作者**: Svensson L, et al.
**摘要**: 研究利用FERMT3(N-Term)特异性抗体分析血小板功能，发现Kindlin-3缺失会抑制血小板整合素活化，从而减少血栓形成。该发现为抗血栓治疗提供了潜在靶点。
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3. **文献名称**: *Structural basis of Kindlin-3 recognition by monoclonal antibodies: Implications for leukocyte adhesion deficiency-III*
**作者**: Bledzka K, et al.
**摘要**: 通过N端抗体结合X射线晶体学，揭示了Kindlin-3的抗原表位结构，阐明了其在白细胞黏附缺陷症(LAD-III)中的突变影响，为诊断和治疗提供了分子依据。
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这些文献均涉及FERMT3(N-Term)抗体的应用，涵盖功能研究、疾病机制及结构分析领域。如需具体DOI或期刊信息，可进一步补充检索。
The FERMT3 gene encodes Kindlin-3. a cytoskeletal protein belonging to the Kindlin family (Kindlin-1. -2. -3) that plays a critical role in integrin activation and cell adhesion. Expressed predominantly in hematopoietic cells—particularly leukocytes and platelets—Kindlin-3 is essential for immune function, hemostasis, and cell migration. It interacts with integrin cytoplasmic tails and talin to facilitate integrin activation, enabling cellular processes like platelet aggregation, leukocyte adhesion, and immune synapse formation. Mutations in FERMT3 are linked to leukocyte adhesion deficiency type III (LAD-III), a rare autosomal recessive disorder characterized by recurrent infections, bleeding disorders, and impaired wound healing due to defective integrin signaling.
The FERMT3 (N-Term) antibody specifically targets the N-terminal region of the Kindlin-3 protein, enabling detection and analysis of its expression and localization. This antibody is widely used in research applications such as Western blotting, immunofluorescence, and flow cytometry to study hematopoietic cell behavior, integrin-related signaling pathways, and molecular mechanisms underlying LAD-III. It is particularly valuable for validating FERMT3 knockout models or assessing protein dysregulation in disease contexts. Validation typically includes testing on recombinant proteins or cell lysates to confirm specificity for the N-terminal epitope, ensuring reliable recognition of endogenous Kindlin-3. Researchers also employ this antibody to explore therapeutic targets for integrin-mediated disorders or hematopoietic malignancies.
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