Rabbit Polyclonal G6PC3 Antibody

G6PC3 (glucose-6-phosphatase catalytic subunit 3) is an enzyme encoded by the *G6PC3* gene, part of the glucose-6-phosphatase family involved in glucose homeostasis. Unlike other isoforms (e.g., G6PC1 in liver), G6PC3 is ubiquitously expressed, particularly in immune cells, and localizes to the endoplasmic reticulum (ER). It catalyzes the hydrolysis of glucose-6-phosphate to glucose, a critical step in glycogenolysis and gluconeogenesis. Research on G6PC3 antibodies stems from its link to G6PC3 deficiency (or severe congenital neutropenia type 4. SCN4), a rare autosomal recessive disorder characterized by neutropenia, impaired neutrophil function, and metabolic anomalies like low blood glucose and lipid abnormalities. Antibodies targeting G6PC3 are vital tools for studying its expression, localization, and molecular interactions in both healthy and diseased states. They enable detection via techniques like Western blotting, immunohistochemistry, and flow cytometry, aiding in understanding how *G6PC3* mutations disrupt ER stress responses, energy metabolism, and immune cell survival. Such studies also explore broader implications in metabolic syndromes, immune dysregulation, and potential therapeutic strategies. Commercially available G6PC3 antibodies are typically validated for specificity across human and model organism tissues, supporting translational research bridging hematology, immunology, and metabolic disease.