Rabbit Polyclonal TAS2R50 Antibody

The TAS2R50 antibody is a research tool designed to target the TAS2R50 protein, a member of the bitter taste receptor (TAS2R) family, which belongs to the G protein-coupled receptor (GPCR) superfamily. TAS2R50. encoded by the TAS2R50 gene, is primarily expressed in taste receptor cells of the tongue, where it detects bitter-tasting compounds as part of a defense mechanism against toxic substances. Beyond gustatory functions, TAS2R50 has been implicated in extraoral tissues, including the respiratory, gastrointestinal, and immune systems, suggesting roles in innate immunity, inflammation, and metabolic regulation. Antibodies against TAS2R50 enable the study of its expression patterns, cellular localization, and signaling mechanisms. These antibodies are typically developed using peptide immunogens corresponding to specific epitopes of the receptor, such as extracellular or intracellular domains. They are validated for applications like immunohistochemistry, Western blotting, and immunofluorescence. Research utilizing TAS2R50 antibodies has explored its involvement in pathogen detection, mucosal defense, and chronic diseases like asthma or diabetes. However, challenges remain in characterizing its ligand specificity and downstream pathways. Such antibodies are critical for deciphering the receptor's physiological and pathological roles, potentially aiding therapeutic targeting for conditions linked to TAS2R dysregulation.