| WB | 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Rho-related GTP-binding protein RhoC, Rho cDNA clone 9, h9, RHOC, ARH9, ARHC |
| Entrez GeneID | 389 |
| WB Predicted band size | 22.0kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | This RHOC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 102-130 amino acids from the C-terminal region of human RHOC. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于RHOC抗体的3篇参考文献的模拟示例(注：文献为虚构，仅供示例参考)：
1. **文献名称**: *RHOC promotes tumor metastasis via EMT in triple-negative breast cancer*
**作者**: Zhang L, et al.
**摘要**: 研究通过免疫组化(使用RHOC抗体)发现，RHOC在转移性三阴性乳腺癌中高表达，并证实其通过激活EMT通路增强肿瘤细胞侵袭能力。
2. **文献名称**: *Targeting RHOC signaling inhibits pancreatic cancer progression*
**作者**: Gupta S, et al.
**摘要**: 利用Western blot(RHOC抗体)及基因沉默技术，证明抑制RHOC可降低胰腺癌细胞迁移，并联合化疗药物显著延缓小鼠模型肿瘤生长。
3. **文献名称**: *RHOC as a prognostic biomarker in ovarian cancer*
**作者**: Wang Y, et al.
**摘要**: 通过组织芯片和RHOC抗体检测，发现RHOC高表达与卵巢癌患者生存率负相关，提示其可作为预后标志物和治疗靶点。
如需实际文献，建议在PubMed或Web of Science中检索关键词“RHOC antibody”“RHOC cancer”等。
RHOC (Ras homolog family member C) is a small GTPase belonging to the Rho subfamily, which regulates cytoskeletal dynamics, cell motility, and intracellular signaling. It plays a critical role in cancer progression, particularly in metastasis, by promoting actin reorganization, invadopodia formation, and epithelial-mesenchymal transition (EMT). RHOC overexpression is linked to aggressive tumor behavior, therapy resistance, and poor prognosis in various cancers, including breast, ovarian, and hepatocellular carcinomas.
RHOC-specific antibodies are essential tools for studying its expression, localization, and function in both physiological and pathological contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding in biomarker discovery and mechanistic research. Commercial RHOC antibodies are typically validated for specificity against conserved regions of the protein, though cross-reactivity with homologous Rho proteins (e.g., RHOA, RHOB) requires careful experimental controls. Recent studies also explore RHOC's role in immune modulation and its potential as a therapeutic target, driving demand for reliable antibodies in preclinical models. Challenges remain in standardizing RHOC detection across tissue types due to variable expression levels and post-translational modifications.
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