| WB | 1/8000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | A-kinase anchor protein 13, AKAP-13, AKAP-Lbc, Breast cancer nuclear receptor-binding auxiliary protein, Guanine nucleotide exchange factor Lbc, Human thyroid-anchoring protein 31, Lymphoid blast crisis oncogene, LBC oncogene, Non-oncogenic Rho GTPase-specific GTP exchange factor, Protein kinase A-anchoring protein 13, PRKA13, p47, AKAP13, BRX, HT31, LBC |
| Entrez GeneID | 11214 |
| WB Predicted band size | 307.6kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This AKAP13 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 18-170 amino acids from human AKAP13. |
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以下是关于AKAP13抗体的3篇假设性参考文献示例(注：以下内容为模拟示例，实际文献需通过数据库检索确认)：
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1. **文献名称**: *AKAP13 regulates RhoA activation and cancer invasion through scaffolding interactions*
**作者**: Smith J, et al.
**摘要**: 本研究利用AKAP13特异性抗体，发现其通过锚定RhoGEF蛋白激活RhoA信号通路，促进乳腺癌细胞的迁移和侵袭，提示AKAP13可作为癌症治疗的潜在靶点。(期刊: *Oncogene*, 2018)
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2. **文献名称**: *A-kinase anchoring protein 13 interacts with PKA to modulate cardiac hypertrophy*
**作者**: Lee H, et al.
**摘要**: 通过AKAP13抗体进行免疫共沉淀实验，证实其在心肌细胞中通过结合蛋白激酶A(PKA)调控病理性心脏肥大的分子机制，为心血管疾病提供新见解。(期刊: *Circulation Research*, 2020)
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3. **文献名称**: *AKAP13 antibody-based profiling reveals tissue-specific expression in developmental models*
**作者**: Brown K, et al.
**摘要**: 该研究开发了一种高特异性AKAP13多克隆抗体，用于检测小鼠胚胎和成体组织中的表达分布，发现其在神经系统和肌肉发育中显著富集。(期刊: *Developmental Biology*, 2019)
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**注意**：以上文献信息为示例性模拟，实际引用时请通过PubMed、Google Scholar等平台检索真实文献，并核对作者、期刊及摘要准确性。
The AKAP13 (A-Kinase Anchoring Protein 13) antibody is a tool used to study the multifunctional scaffolding protein AKAP13. which plays a critical role in cellular signaling. AKAP13. also known as BRX or LBK, belongs to the AKAP family, known for binding to the regulatory subunit of protein kinase A (PKA) and localizing it to specific subcellular compartments. AKAP13 uniquely integrates multiple signaling pathways by interacting with PKA, PKC, and other kinases, while its RhoGEF domain activates Rho GTPases, modulating cytoskeletal dynamics, gene transcription, and cell cycle progression. This protein is implicated in processes like cell proliferation, differentiation, and stress responses, with dysregulation linked to cancers, cardiovascular diseases, and immune disorders.
Antibodies targeting AKAP13 enable researchers to investigate its expression, localization, and interactions in various tissues and disease models. They are widely used in techniques such as Western blotting, immunohistochemistry, and co-immunoprecipitation to explore AKAP13's role in signaling cascades. Studies using AKAP13 antibodies have highlighted its oncogenic potential, particularly in breast cancer and leukemia, where it may drive metastasis or therapy resistance. Additionally, these antibodies aid in elucidating AKAP13's function in cardiac hypertrophy and vascular remodeling. Validation of antibody specificity remains crucial, as AKAP13 exhibits multiple isoforms due to alternative splicing, requiring careful selection for experimental accuracy.
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