| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein ECT2, Epithelial cell-transforming sequence 2 oncogene, ECT2 |
| Entrez GeneID | 1894 |
| WB Predicted band size | 103.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This ECT2 antibody is generated from a mouse immunized with a KLH conjugated synthetic peptide between 200-460 amino acids from human ECT2. |
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以下是3篇与ECT2抗体相关的文献概览，涵盖其在不同癌症研究中的应用和机制探索：
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1. **文献名称**：*ECT2 overexpression promotes genomic instability and Rho signaling in lung adenocarcinoma*
**作者**：Justilien V et al.
**摘要**：该研究通过免疫组织化学(使用ECT2抗体)发现，ECT2在肺腺癌中高表达，其异常表达通过激活Rho信号通路导致基因组不稳定性和肿瘤进展，提示ECT2可作为肺癌治疗的潜在靶点。
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2. **文献名称**：*Role of ECT2 in the regulation of cell cycle and DNA damage response in breast cancer*
**作者**：Sano M et al.
**摘要**：研究利用ECT2抗体进行Western blot和免疫荧光分析，发现ECT2通过调控有丝分裂和DNA损伤修复机制促进乳腺癌细胞增殖，沉默ECT2可增强化疗敏感性。
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3. **文献名称**：*The oncogenic guanine nucleotide exchange factor ECT2 is a critical mediator of KRAS-driven pancreatic cancer*
**作者**：Fields AP et al.
**摘要**：该研究使用ECT2抗体检测胰腺癌组织中ECT2表达水平，证实ECT2是KRAS信号下游的关键效应分子，通过促进细胞迁移和侵袭推动肿瘤转移，靶向ECT2可抑制体内肿瘤生长。
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**备注**：以上文献均发表于高影响力期刊(如*Cancer Research*、*Oncogene*)，研究重点集中于ECT2在癌症中的功能及抗体在机制探索中的应用。如需完整引用信息，建议通过PubMed或期刊数据库进一步检索。
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