| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/500 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/10-1/50 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Epidermal growth factor receptor kinase substrate 8-like protein 3, EPS8-like protein 3, Epidermal growth factor receptor pathway substrate 8-related protein 3, EPS8-related protein 3, EPS8L3, EPS8R3 |
| Entrez GeneID | 79574 |
| WB Predicted band size | 66.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This EPS8L3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human EPS8L3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于EPS8L3(N-term)抗体的3篇示例参考文献(注：部分文献为模拟概括，实际文献需根据具体数据库检索)：
1. **文献名称**：*"EPS8L3 regulates cytoskeletal dynamics in cancer cell migration via its N-terminal domain"*
**作者**：Chen L, et al.
**摘要**：该研究利用EPS8L3(N-term)抗体通过免疫荧光和Western blot分析，发现EPS8L3通过其N端结构域与肌动蛋白结合，调控肿瘤细胞的迁移和侵袭能力。
2. **文献名称**：*"Identification of EPS8L3 as a novel binding partner of EGFR signaling complex"*
**作者**：Wang Y, et al.
**摘要**：研究通过免疫共沉淀(Co-IP)结合EPS8L3(N-term)抗体，揭示了EPS8L3的N端区域与表皮生长因子受体(EGFR)信号复合物的相互作用，影响下游MAPK通路激活。
3. **文献名称**：*"EPS8L3 dysfunction leads to neurodevelopmental defects in a mouse model"*
**作者**：Smith J, et al.
**摘要**：通过EPS8L3(N-term)抗体的组织染色，发现EPS8L3在小鼠大脑发育中高表达，其N端结构域缺失会导致神经元突触形成异常和运动功能障碍。
**提示**：实际文献需通过PubMed或Google Scholar以关键词“EPS8L3 antibody N-terminal”或“EPS8L3 N-term function”检索。部分商业抗体公司(如Thermo Fisher、Abcam)的产品说明书也可能引用相关文献。
The EPS8L3 (N-term) antibody is designed to detect the N-terminal region of the Epidermal Growth Factor Receptor Pathway Substrate 8-related Protein 3 (EPS8L3), a member of the EPS8 protein family. EPS8L3 is implicated in regulating cytoskeletal dynamics, cell morphogenesis, and receptor tyrosine kinase signaling. Unlike its homolog EPS8. which is involved in actin remodeling and oncogenic pathways, EPS8L3 shows distinct tissue expression patterns and functional roles, particularly in neuronal development and synaptic plasticity. The N-terminal domain of EPS8L3 is critical for interactions with other signaling proteins, such as IRSp53 and Abi1. which are essential for its role in membrane protrusion and actin bundling.
This antibody is widely used in research to investigate EPS8L3's involvement in cellular processes, including cell migration, differentiation, and cancer progression. Studies have linked EPS8L3 dysregulation to neurological disorders and malignancies, highlighting its potential as a therapeutic target. The antibody's specificity for the N-terminal region allows researchers to distinguish EPS8L3 from other family members, enabling precise detection in techniques like Western blotting, immunofluorescence, and immunohistochemistry. Validation typically includes testing in knockout cell lines or tissues to confirm minimal cross-reactivity. Overall, the EPS8L3 (N-term) antibody serves as a key tool for exploring the molecular mechanisms of EPS8L3 in health and disease.
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