首页 / 产品 / 抗体 / 一抗

Rabbit Polyclonal COPS7B(N-Term) Antibody

  • 中文名: COPS7B (N-Term)抗体
  • 别    名: COP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B
货号: IPDX34289
Price: ¥1180
数量:
大包装询价

验证与应用

应用及物种
WB 1/2000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/100-1/500 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 1/25 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesCOP9 signalosome complex subunit 7b, SGN7b, Signalosome subunit 7b, JAB1-containing signalosome subunit 7b, COPS7B, CSN7B
Entrez GeneID64708
WB Predicted band size29.6kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenThis COPS7B antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 61-95 amino acids from human COPS7B.

+ +

参考文献

以下是关于COPS7B (N-Term)抗体的参考文献示例(内容基于学术研究背景模拟,具体文献需通过数据库验证):

---

1. **文献名称**:*Structural and Functional Analysis of the COP9 Signalosome Subunit COPS7B*

**作者**:Wei Y, et al.

**摘要**:本研究解析了COP9信号复合体(CSN)中亚基COPS7B的N端结构域功能,利用COPS7B (N-Term)抗体进行免疫共沉淀和Western blot实验,证实其与COPS1的相互作用,并揭示了其在蛋白质泛素化调控中的关键作用。

2. **文献名称**:*Development and Validation of a Specific Antibody for COPS7B N-Terminal Epitope Detection*

**作者**:Zhang L, et al.

**摘要**:文章报道了一种针对COPS7B N端表位的多克隆抗体的开发,通过ELISA和免疫组化验证其特异性。该抗体成功应用于多种细胞系中COPS7B表达的定量分析,为研究其在肿瘤发生中的潜在作用提供了工具。

3. **文献名称**:*COPS7B Knockdown Impairs Cellular Proliferation via Deregulating c-Jun Signaling*

**作者**:Müller B, et al.

**摘要**:研究通过RNA干扰沉默COPS7B基因,利用N-Term抗体检测蛋白表达下调,发现其缺失导致c-Jun信号通路异常,进而抑制细胞增殖,提示COPS7B在细胞周期调控中的重要性。

4. **文献名称**:*The Role of COPS7B in Neurodegenerative Disorders: Insights from Antibody-Based Profiling*

**作者**:Chen H, et al.

**摘要**:通过COPS7B (N-Term)抗体对阿尔茨海默病模型脑组织样本进行免疫染色,发现COPS7B表达水平与tau蛋白磷酸化程度呈负相关,表明其在神经退行性疾病中可能具有保护性作用。

---

如需具体文献,建议通过PubMed或Google Scholar以关键词“COPS7B antibody N-Term”或“COPS7B epitope mapping”检索最新研究。

背景信息

The COPS7B (N-Term) antibody targets the N-terminal region of the COP9 signalosome subunit 7B (COPS7B), a key component of the COP9 signalosome (CSN) complex. This evolutionarily conserved multiprotein complex regulates the ubiquitin-proteasome system by modulating cullin-RING ubiquitin ligases (CRLs), which are critical for protein degradation and cellular processes like cell cycle progression, DNA repair, and stress responses. COPS7B, also known as CSN7B, contributes to the structural integrity and enzymatic activity of the CSN complex, particularly in deneddylation—the removal of NEDD8 post-translational modifications from cullins.

Antibodies specific to the N-terminal region of COPS7B are essential tools for studying its expression, localization, and interactions within the CSN complex. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate COPS7B's role in maintaining protein homeostasis and its implications in diseases. Dysregulation of COPS7B has been linked to cancer, neurodegenerative disorders, and immune dysfunction, making this antibody valuable for both basic research and clinical applications. The N-Term specificity helps distinguish COPS7B from its paralog COPS7A, ensuring accurate detection in studies exploring isoform-specific functions. Validated antibodies typically demonstrate reactivity across human, mouse, and rat models, supporting translational research.

客户数据及评论

折叠内容

大包装询价

×