Rabbit Polyclonal INTS9 Antibody

INTS9 (Integrator Complex Subunit 9) is a protein component of the Integrator complex, a multi-subunit assembly involved in RNA processing and transcriptional regulation. Discovered as part of a conserved metazoan complex, the Integrator plays critical roles in the 3' end processing of small nuclear RNAs (snRNAs) and enhancer-derived RNAs (eRNAs), as well as in modulating RNA polymerase II (RNAPII) activity. INTS9. along with other subunits (INTS1–INTS14), contributes to the structural and functional integrity of the complex. Studies suggest that INTS9 is essential for proper snRNA biogenesis, interacting with RNAPII and cleavage/polyadenylation machinery to ensure accurate transcript termination. Dysregulation of INTS9 has been linked to developmental defects and diseases, including cancer, where altered Integrator function may influence oncogenic gene expression. Antibodies targeting INTS9 are vital tools for investigating its molecular interactions, localization, and mechanistic roles in RNA processing. They enable applications such as immunoprecipitation, Western blotting, and immunofluorescence, helping to dissect the Integrator's involvement in transcriptional pause-release, epigenetic regulation, and non-coding RNA biology. Validated INTS9 antibodies are crucial for studies aiming to explore its potential as a therapeutic target or biomarker in disease contexts.