Rabbit Polyclonal TMX1 Antibody

The TMX1 (Thioredoxin-Related Transmembrane Protein 1) antibody is a tool used to study the TMX1 protein, a member of the thioredoxin superfamily localized primarily in the endoplasmic reticulum (ER). TMX1 plays a critical role in redox regulation, protein folding, and quality control within the ER by catalyzing disulfide bond formation/isomerization. Unlike cytosolic thioredoxins, TMX1 contains a transmembrane domain, anchoring it to the ER membrane, and a C-terminal PDI-like thioredoxin domain. Research highlights its involvement in ER stress responses, calcium homeostasis, and interactions with chaperones like calnexin. TMX1 is implicated in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes, where ER dysfunction is a hallmark. The TMX1 antibody (often rabbit or mouse-derived, polyclonal/monoclonal) enables detection and localization of TMX1 via techniques like Western blot, immunofluorescence, and immunoprecipitation. Its specificity is validated through knockout controls or siRNA silencing. Studies using this antibody have revealed TMX1's context-dependent roles—acting as both a pro-survival factor during mild stress and a pro-apoptotic signal under severe ER stress. Ongoing research focuses on its therapeutic potential in modulating ER-related pathologies.