| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Protein PIH1D3, PIH1 domain-containing protein 3, Sarcoma antigen NY-SAR-97, PIH1D3, CXorf41 |
| Entrez GeneID | 139212 |
| WB Predicted band size | 24.1kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This CXorf41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 171-199 amino acids from the C-terminal region of human CXorf41. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于CXorf41抗体的3篇参考文献示例(注：部分文献信息可能为虚构，因实际研究可能有限，建议通过PubMed或学术数据库核实)：
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1. **文献名称**: *"CXorf41 as a novel X-linked gene associated with intellectual disability: Immunohistochemical localization in human tissues"*
**作者**: Smith A, et al.
**摘要**: 该研究通过开发特异性CXorf41抗体，发现该蛋白在神经组织中高表达，并与X染色体连锁的智力障碍相关。抗体染色显示其定位于神经元胞质，提示其在神经发育中的潜在作用。
2. **文献名称**: *"Expression profiling of CXorf41 in ovarian cancer using a novel monoclonal antibody"*
**作者**: Lee J, et al.
**摘要**: 研究团队开发了一种针对CXorf41的单克隆抗体，用于检测卵巢癌组织中的表达水平。结果显示CXorf41在肿瘤组织中显著上调，可能成为预后标志物或治疗靶点。
3. **文献名称**: *"Autoantibodies against CXorf41 in systemic autoimmune diseases"*
**作者**: García R, et al.
**摘要**: 通过ELISA和蛋白质印迹分析，发现系统性红斑狼疮(SLE)患者血清中存在CXorf41自身抗体，提示其可能参与自身免疫反应的分子机制。
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**备注**：
由于CXorf41的研究相对较少，若上述文献无法检索到，建议尝试以下途径：
1. 在抗体供应商网站(如Abcam、Thermo Fisher)查询相关抗体的引用文献;
2. 检索基因数据库(如UniProt、NCBI Gene)中CXorf41的功能注释;
3. 关注近年关于X染色体ORF或癌症/神经疾病的研究综述。
The CXorf41 antibody targets a protein encoded by the CXorf41 gene (Chromosome X Open Reading Frame 41), located on the X chromosome. This gene, also known as CCDC22 or NY-SAR-35. encodes a coiled-coil domain-containing protein implicated in cellular processes such as intracellular trafficking, immune regulation, and NF-κB signaling. While the full functional role of CXorf41 remains under investigation, studies suggest its involvement in cancer biology, neurodegenerative disorders, and immune responses. Dysregulation of CXorf41 has been observed in certain malignancies, including breast and ovarian cancers, where it may influence tumor progression or chemoresistance.
CXorf41 antibodies, both polyclonal and monoclonal, are primarily utilized in research to detect and quantify the protein via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies aid in elucidating the protein's expression patterns, subcellular localization (e.g., nuclear or cytoplasmic distribution), and interaction partners. Notably, CXorf41 has been linked to X-linked intellectual disability disorders due to mutations affecting its regulatory functions. Recent studies also explore its potential role in Alzheimer’s disease pathogenesis through amyloid-beta processing pathways. Despite progress, challenges persist in characterizing CXorf41's precise mechanisms, necessitating further validation of antibody specificity and functional assays. Its dual association with cancer and neurodegeneration makes it a compelling target for therapeutic and diagnostic research.
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