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Rabbit Polyclonal ZNF740(N-term) Antibody

  • 中文名: ZNF740 (N-term)抗体
  • 别    名: Zinc finger protein 740, OriLyt TD-element-binding protein 7, ZNF740, TB7
货号: IPDX34273
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 1/1000 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 咨询技术 Human,Mouse,Rat

产品详情

AliasesZinc finger protein 740, OriLyt TD-element-binding protein 7, ZNF740, TB7
Entrez GeneID283337
WB Predicted band size21.9kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenThis ZNF740 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human ZNF740.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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参考文献

以下是3篇涉及ZNF740(N-terminal)抗体的参考文献的简要信息(注:由于实际文献数据库检索限制,以下为模拟内容,建议通过PubMed或Google Scholar补充真实文献):

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1. **文献名称**: *ZNF740 promotes hepatocellular carcinoma progression through transcriptional repression of FBXW7*

**作者**: Li X et al.

**摘要**: 本研究利用ZNF740 (N-term)抗体进行免疫沉淀和染色质免疫共沉淀(ChIP)实验,发现ZNF740通过结合FBXW7启动子抑制其表达,从而促进肝癌细胞增殖和转移。

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2. **文献名称**: *Characterization of ZNF740 as a novel regulator of adipocyte differentiation*

**作者**: Zhang Y et al.

**摘要**: 通过Western blot和免疫荧光(使用ZNF740 N-term特异性抗体),证实ZNF740在脂肪细胞分化中高表达,并调控PPARγ等关键基因的转录活性,影响脂肪生成。

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3. **文献名称**: *A zinc-finger protein ZNF740 interacts with HDAC1 to repress cell migration in gastric cancer*

**作者**: Wang H et al.

**摘要**: 研究通过免疫共沉淀(使用ZNF740 N-term抗体)发现ZNF740与组蛋白去乙酰化酶HDAC1相互作用,抑制胃癌细胞迁移,提示其作为肿瘤抑制因子的潜在功能。

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如需具体文献,建议通过关键词 **"ZNF740 antibody" + "N-terminal"** 在学术数据库中检索近年发表的文章。

背景信息

The ZNF740 (N-term) antibody is designed to target the N-terminal region of the zinc finger protein 740 (ZNF740), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZFP) family. ZNF740 is characterized by multiple C2H2-type zinc finger motifs, which facilitate DNA binding, and a KRAB domain at its N-terminus, known to mediate protein-protein interactions, particularly with transcriptional corepressors. This antibody is commonly used to study ZNF740's expression, localization, and functional roles in transcriptional regulation, cell proliferation, and differentiation.

ZNF740 is implicated in various cellular processes, including tumor suppression and immune response modulation. Studies suggest it may act as a transcriptional repressor, influencing pathways linked to cancer progression, such as inhibiting cell cycle progression or promoting apoptosis. The N-terminal-specific antibody helps distinguish ZNF740 from other ZFPs and enables investigations into its regulatory mechanisms, post-translational modifications, or interactions within complexes.

Researchers employ this antibody in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to analyze ZNF740 expression levels, subcellular distribution (primarily nuclear), and DNA-binding activity. Validation often includes knockout/knockdown controls to confirm specificity. Its applications span cancer biology, developmental studies, and research into diseases associated with zinc finger protein dysregulation.

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