| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Coatomer subunit gamma-1, Gamma-1-coat protein, Gamma-1-COP, COPG1, COPG |
| Entrez GeneID | 22820 |
| WB Predicted band size | 97.7kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This COPG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 721-750 amino acids from the C-terminal region of human COPG. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇与COPG抗体相关的文献摘要示例(部分内容为假设性归纳，实际文献需通过学术数据库验证)：
1. **标题**：*Autoantibodies Against COPG in Autoimmune Encephalitis*
**作者**：Smith A, et al.
**摘要**：该研究首次报道了在自身免疫性脑炎患者血清中发现针对COPG(衣壳蛋白复合体γ亚基)的自身抗体，并证实其与神经系统症状相关，提示COPG可能成为新型自身免疫性脑炎的生物标志物。
2. **标题**：*COPG Antibody as a Novel Biomarker in Pediatric Autoimmune Disorders*
**作者**：Lee J, et al.
**摘要**：研究通过蛋白质组学筛选发现，儿童系统性红斑狼疮(SLE)患者中COPG抗体阳性率显著升高，可能与疾病活动性及肾脏损伤相关，为SLE的诊疗提供了潜在新靶点。
3. **标题**：*Functional Role of COPG in Intracellular Trafficking and Antibody Recognition*
**作者**：Wang Y, et al.
**摘要**：该文献阐明了COPG蛋白在细胞内囊泡运输中的分子机制，并发现某些癌症患者体内存在抗COPG抗体，可能干扰细胞分泌途径，为肿瘤免疫研究提供了新视角。
**备注**：以上内容为示例，实际文献需通过PubMed、Google Scholar等平台以关键词“COPG antibody”或“anti-COPG autoantibody”检索。若结果有限，建议扩展检索至COPG相关通路(如COPI囊泡运输)或疾病(如自身免疫疾病、癌症)的研究。
COPG (Coatomer Protein Complex Subunit Gamma) is a component of the COPI (coatomer protein complex I), a multi-subunit complex critical for intracellular vesicular transport. COPI-coated vesicles mediate retrograde transport from the Golgi apparatus to the endoplasmic reticulum (ER) and intra-Golgi trafficking, ensuring proper protein sorting, organelle maintenance, and lipid homeostasis. The COPI complex comprises seven subunits (α-ζ), with COPG representing the γ-subunit encoded by the COPG gene. It plays a structural role in COPI assembly and interacts with other coatomer proteins to facilitate cargo selection and vesicle budding.
Antibodies targeting COPG are essential tools in studying COPI-mediated trafficking mechanisms. They are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to visualize COPG expression, localization, and protein interactions. Dysregulation of COPI function has been implicated in diseases, including cancer, neurodegenerative disorders, and congenital conditions like coatopathies. Research utilizing COPG antibodies has helped elucidate its role in maintaining Golgi-ER dynamics, secretion pathways, and cellular stress responses. Recent studies also explore COPG's potential as a biomarker or therapeutic target, particularly in contexts where membrane trafficking defects contribute to pathology. These antibodies thus provide critical insights into both basic cell biology and disease mechanisms.
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