| WB | 1/500 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 8A1, OST025, Olfactory receptor OR11-318, OR8A1 |
| Entrez GeneID | 390275 |
| WB Predicted band size | 36.4kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR8A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-39 amino acids from the N-terminal region of human OR8A1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于OR8A1(N-term)抗体的3篇参考文献，包含文献名称、作者及摘要内容概括：
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1. **文献名称**：*"Characterization of Olfactory Receptor OR8A1 Expression in Human Tissues Using a Novel N-Terminal Specific Antibody"*
**作者**：Smith J, et al.
**摘要**：本研究开发了一种针对OR8A1蛋白N端表位的多克隆抗体，并通过免疫组化和Western blot验证其特异性。结果显示OR8A1在嗅觉上皮和睾丸组织中特异性表达，提示其在化学感知和生殖系统中的潜在功能。
2. **文献名称**：*"Functional Analysis of OR8A1 in Odorant Signal Transduction via CRISPR/Cas9 and Antibody-Based Detection"*
**作者**：Chen L, et al.
**摘要**：利用CRISPR/Cas9技术敲除OR8A1基因，结合N端抗体检测蛋白表达变化，发现OR8A1缺失导致特定挥发性分子(如萜烯类)的嗅觉信号传导受损，表明其在气味识别中的关键作用。
3. **文献名称**：*"Antibody Screening for GPCR Localization: A Case Study on OR8A1 in Neuronal Membranes"*
**作者**：Gomez R, et al.
**摘要**：通过免疫荧光和共聚焦显微镜，使用OR8A1(N-term)抗体证实该受体主要定位于神经元细胞膜，并参与G蛋白偶联的cAMP信号通路调控，为嗅觉受体亚细胞定位研究提供了新工具。
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**说明**：上述文献为示例性内容，实际研究中OR8A1抗体相关论文可能较少，建议通过PubMed或抗体生产商(如Sigma、Abcam)的产品引用列表获取具体文献。
The OR8A1 (N-term) antibody is a polyclonal or monoclonal reagent designed to target the N-terminal region of the olfactory receptor 8A1 (OR8A1), a member of the G protein-coupled receptor (GPCR) superfamily. OR8A1 is an olfactory receptor primarily expressed in olfactory sensory neurons, where it plays a role in detecting odorant molecules and initiating signal transduction pathways. This antibody is commonly used in research applications such as Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to study OR8A1 expression, localization, and function in biological samples.
The N-terminal region of OR8A1 is critical for ligand binding and receptor activation, making this antibody a valuable tool for investigating the receptor's structural and mechanistic properties. It is often validated for specificity using knockout controls or peptide blocking assays to ensure minimal cross-reactivity with other olfactory receptors. Researchers utilize this antibody to explore OR8A1's involvement in olfactory signaling, its potential roles in non-olfactory tissues, and its implications in diseases or disorders linked to olfactory dysfunction.
The antibody is typically raised in hosts like rabbits or mice, with reactivity confirmed in human, mouse, or rat samples depending on the product. Storage conditions usually recommend -20°C for long-term preservation. Its applications contribute to advancing studies in neurobiology, sensory perception, and molecular pharmacology.
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