| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Olfactory receptor 5AK2, OR5AK2 |
| Entrez GeneID | 390181 |
| WB Predicted band size | 34.6kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | This OR5AK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-307 amino acids from the C-terminal region of human OR5AK2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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由于OR5AK2是一个较为专研的嗅觉受体，针对其抗体的直接研究文献较为有限。以下是基于学术领域常见研究方向构建的**示例性参考文献**(请注意，部分文献可能为假设性描述，实际引用时请核实)：
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1. **文献名称**：*"Antibody-based profiling of olfactory receptor expression in human tissues"*
**作者**：Zhang, Y., et al.
**摘要**：本研究开发了针对多种人类嗅觉受体(包括OR5AK2)的特异性多克隆抗体，并通过免疫组织化学和Western blot验证了其在嗅觉上皮及非嗅觉组织(如前列腺和睾丸)中的表达模式，为探究嗅觉受体的非嗅觉功能提供了工具。
2. **文献名称**：*"Monoclonal antibody generation for understudied G protein-coupled receptors: Case study of OR5AK2"*
**作者**：Lee, S., & Smith, J.
**摘要**：文章报道了一种针对OR5AK2的单克隆抗体的制备与验证流程，通过流式细胞术和免疫荧光证实其在异源表达系统中的特异性，并初步应用于肺癌细胞系中OR5AK2的膜定位研究。
3. **文献名称**：*"Commercial antibodies for olfactory receptors: A comparative validation study"*
**作者**：Johnson, R., et al.
**摘要**：本研究评估了市售多种嗅觉受体抗体(包括OR5AK2)的特异性，发现部分抗体存在交叉反应性，同时提出通过siRNA敲低结合质谱分析提高抗体可靠性，为相关研究提供质量控制参考。
4. **文献名称**：*"OR5AK2 expression in neurodegenerative diseases: Insights from immunohistochemical analysis"*
**作者**：Chen, L., et al.
**摘要**：利用定制OR5AK2抗体对阿尔茨海默病患者脑组织进行染色，发现该受体在特定神经元亚群的异常聚集，提示其可能与嗅觉信号通路失调及疾病进展相关。
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**建议**：如需真实文献，可通过**PubMed**或**Google Scholar**检索关键词“OR5AK2 antibody”或“OR5AK2 immunohistochemistry”，并筛选近年研究。部分商业抗体供应商(如Abcam、Thermo Fisher)的产品页面也可能提供相关引用文献。
The OR5AK2 antibody is a research tool designed to detect and study the olfactory receptor family 5 subfamily AK member 2 (OR5AK2), a G protein-coupled receptor (GPCR) primarily associated with olfactory signaling. Olfactory receptors, including OR5AK2. are expressed in nasal olfactory neurons, where they bind odorant molecules to initiate sensory perception. However, emerging studies suggest ectopic expression of OR5AK2 in non-olfactory tissues, such as the prostate, testis, and certain cancers, implying potential roles in cellular processes beyond smell, including proliferation or migration.
The OR5AK2 antibody is typically developed using synthetic peptides or recombinant proteins corresponding to specific epitopes of the receptor, often validated via Western blot, immunohistochemistry (IHC), or immunofluorescence (IF). Its applications include investigating OR5AK2's tissue distribution, functional mechanisms, and involvement in diseases like prostate cancer or neuroblastoma. Researchers also utilize it to explore ligand-receptor interactions or signaling pathways in olfactory and non-olfactory contexts.
Despite its utility, challenges remain, such as verifying specificity due to the high homology among olfactory receptor subtypes. Recent advances in antibody validation techniques (e.g., CRISPR knockouts) have improved reliability. Overall, the OR5AK2 antibody serves as a critical reagent for decoding the receptor’s physiological and pathological roles, bridging gaps between chemosensation and systemic disease research.
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