| WB | 1/1000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 咨询技术 | Human,Mouse,Rat |
| Aliases | Pregnancy-specific beta-1-glycoprotein 3, PS-beta-G-3, PSBG-3, Pregnancy-specific glycoprotein 3, Carcinoembryonic antigen SG5, PSG3 |
| Entrez GeneID | 5671 |
| WB Predicted band size | 47.9kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This PSG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22-50 amino acids from the N-terminal region of human PSG3. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于PSG3 (N-term)抗体的参考文献示例(内容为虚构，仅供示例用途)：
1. **文献名称**：*Monoclonal Antibody Targeting the N-Terminus of PSG3: Development and Application in Placental Research*
**作者**：Smith J, et al.
**摘要**：该研究描述了一种针对PSG3蛋白N端表位的单克隆抗体的开发，验证了其在胎盘组织免疫组化中的特异性，并用于探究PSG3在妊娠早期中的表达模式。
2. **文献名称**：*PSG3 N-Terminal Antibody Validation for Serum Biomarker Detection in Preeclampsia*
**作者**：Johnson L, Lee R
**摘要**：研究团队开发了兔源多克隆抗体，针对PSG3的N端区域，通过ELISA技术检测孕妇血清中的PSG3水平，评估其作为子痫前期生物标志物的潜力。
3. **文献名称**：*Epitope-Specific Antibodies Reveal PSG3 N-Terminal Domain Function in Cell Adhesion*
**作者**：Brown K, et al.
**摘要**：通过生成针对PSG3不同结构域的抗体，研究发现N端抗体可阻断PSG3介导的细胞粘附作用，提示该区域在母胎界面的生理调控中起关键作用。
4. **文献名称**：*Comparative Analysis of PSG3 Antibody Performance in Western Blot and Immunofluorescence*
**作者**：Zhang Y, et al.
**摘要**：研究对比了多种PSG3抗体(包括N端特异性抗体)的灵敏度和特异性，证实其在Western blot和细胞免疫荧光中的可靠性，为后续功能研究提供工具支持。
(注：以上文献信息为模拟生成，实际引用需查询真实数据库。)
**Background of PSG3 (N-term) Antibody**
Pregnancy-specific glycoprotein 3 (PSG3) is a member of the PSG family, part of the carcinoembryonic antigen-related cell adhesion molecule (CEACAM) superfamily. These glycoproteins are predominantly expressed in the placenta during pregnancy and play critical roles in immune modulation, angiogenesis, and trophoblast function. PSG3. encoded by the *PSG3* gene, is involved in promoting maternal-fetal tolerance and regulating cellular interactions at the maternal-fetal interface.
The PSG3 (N-term) antibody is designed to target the N-terminal region of the PSG3 protein, enabling the detection and study of its expression, localization, and function. This antibody is commonly used in applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate PSG3 in placental tissues, cancer biology (due to CEACAM-related oncogenic associations), and pregnancy-related disorders like preeclampsia or intrauterine growth restriction.
As a research tool, the PSG3 (N-term) antibody aids in elucidating the molecular mechanisms underlying PSG3-mediated immune regulation and its potential role in pathological conditions. Validated for specificity and sensitivity, it supports studies exploring PSG3's interaction with immune receptors (e.g., TIM-3) and its impact on cytokine secretion. Its development has advanced both reproductive biology and oncology research, highlighting PSG3 as a biomarker or therapeutic target in pregnancy complications and certain cancers.
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